Genome rewriting generates mouse models of human diseases

被引：1
|
作者：
Ordonez, Raquel [1 ]
Zhang, Weimin [1 ]
机构：
[1] NYU Langone Hlth, New York, NY 10016 USA
来源：
NATURE | 2023年
关键词：
Genomics; Genetics; SARS-CoV-2; SARS-COV-2;
D O I：
10.1038/d41586-023-03079-2
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Many human diseases lack accurate mouse models because it is technically difficult to create extensively genetically humanized mice. A technique that allows large stretches of DNA to be rapidly rewritten in mouse embryonic stem cells can be used to produce improved animal models. A technique to place human DNA in mouse embryonic stem cells improves animal models of diseases such as COVID-19.
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页数：2
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