Antibacterial activity of novel bacterial topoisomerase inhibitors against key veterinary pathogens

被引：0

作者：

Phelps, Hilary A. ^{[1
]}

Kuhn, Michael ^{[1
]}

Lu, Yanran ^{[2
]}

Vibhute, Sandip ^{[2
,4
]}

Watts, Jeffrey L. ^{[1
]}

Mitton-Fry, Mark J. ^{[2
,3
]}

机构：

[1] Zoetis, Global Therapeut, Anti Infect Res, 333 Portage St, Kalamazoo, MI 49007 USA

[2] Ohio State Univ, Coll Pharm, Div Med Chem & Pharmacognosy, 500 West 12th Ave, Columbus, OH 43210 USA

[3] 500 West 12th Ave, Columbus, OH 43210 USA

[4] Ohio State Univ, Comprehens Canc Ctr, Columbus, OH 43210 USA

来源：

VETERINARY MICROBIOLOGY | 2023年 / 284卷

关键词：

Antagonists & amp; Inhibitors; Mastitis; Staphylococcus; ANTIMICROBIAL RESISTANCE; MASTITIS;

D O I：

10.1016/j.vetmic.2023.109840

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Multidrug-resistant bacteria infect companion animals and livestock in addition to their devastating impact on human health. Novel Bacterial Topoisomerase Inhibitors (NBTIs) with excellent activity against Gram-positive bacteria have previously been identified as promising new antibacterial agents. Herein, we evaluate the antibacterial activity of these NBTIs against a variety of important veterinary pathogens and demonstrate outstanding in vitro activity, especially against staphylococci.

引用

页数：5

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