Antibacterial activity of novel bacterial topoisomerase inhibitors against key veterinary pathogens

被引：0
|
作者：
Phelps, Hilary A. [1 ]
Kuhn, Michael [1 ]
Lu, Yanran [2 ]
Vibhute, Sandip [2 ,4 ]
Watts, Jeffrey L. [1 ]
Mitton-Fry, Mark J. [2 ,3 ]
机构：
[1] Zoetis, Global Therapeut, Anti Infect Res, 333 Portage St, Kalamazoo, MI 49007 USA
[2] Ohio State Univ, Coll Pharm, Div Med Chem & Pharmacognosy, 500 West 12th Ave, Columbus, OH 43210 USA
[3] 500 West 12th Ave, Columbus, OH 43210 USA
[4] Ohio State Univ, Comprehens Canc Ctr, Columbus, OH 43210 USA
来源：
VETERINARY MICROBIOLOGY | 2023年 / 284卷
关键词：
Antagonists & amp; Inhibitors; Mastitis; Staphylococcus; ANTIMICROBIAL RESISTANCE; MASTITIS;
D O I：
10.1016/j.vetmic.2023.109840
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Multidrug-resistant bacteria infect companion animals and livestock in addition to their devastating impact on human health. Novel Bacterial Topoisomerase Inhibitors (NBTIs) with excellent activity against Gram-positive bacteria have previously been identified as promising new antibacterial agents. Herein, we evaluate the antibacterial activity of these NBTIs against a variety of important veterinary pathogens and demonstrate outstanding in vitro activity, especially against staphylococci.
引用
收藏
页数：5
相关论文
共 50 条
  • [21] Novel MreB inhibitors with antibacterial activity against Gram (-) bacteria
    Sagong, Hye Yeon
    Rosado-Lugo, Jesus D.
    Bryan, Eric J.
    Ferrer-Gonzalez, Edgar
    Wang, Yiling
    Cao, Yanlu
    Parhi, Ajit K.
    Pilch, Daniel S.
    LaVoie, Edmond J.
    MEDICINAL CHEMISTRY RESEARCH, 2022, 31 (10) : 1679 - 1704
  • [22] Novel MreB inhibitors with antibacterial activity against Gram (-) bacteria
    Hye Yeon Sagong
    Jesus D. Rosado-Lugo
    Eric J. Bryan
    Edgar Ferrer-González
    Yiling Wang
    Yanlu Cao
    Ajit K. Parhi
    Daniel S. Pilch
    Edmond J. LaVoie
    Medicinal Chemistry Research, 2022, 31 : 1679 - 1704
  • [23] Monoclonal Antibodies as an Antibacterial Approach Against Bacterial Pathogens
    Zurawski, Daniel V.
    McLendon, Molly K.
    ANTIBIOTICS-BASEL, 2020, 9 (04):
  • [24] Antibacterial activity against porcine respiratory bacterial pathogens and in vitro biocompatibility of essential oils
    Geneviève LeBel
    Katy Vaillancourt
    Philippe Bercier
    Daniel Grenier
    Archives of Microbiology, 2019, 201 : 833 - 840
  • [25] Advances in Antibacterial Therapy Against Emerging Bacterial Pathogens
    Pournaras, Spyros
    Iosifidis, Elias
    Roilides, Emmanuel
    SEMINARS IN HEMATOLOGY, 2009, 46 (03) : 198 - 211
  • [26] Antibacterial activity against porcine respiratory bacterial pathogens and in vitro biocompatibility of essential oils
    LeBel, Genevieve
    Vaillancourt, Katy
    Bercier, Philippe
    Grenier, Daniel
    ARCHIVES OF MICROBIOLOGY, 2019, 201 (06) : 833 - 840
  • [27] Antibacterial Activity of Glycyrrhiza Glabra Roots against food-borne bacterial pathogens
    Eshghi, N.
    Ghasemian, S. O.
    Malekirad, A. A.
    Dehnamaki, F.
    Abdi, S.
    Malekabad, E. Shiri
    Rezaei, M.
    WEST INDIAN MEDICAL JOURNAL, 2019, 68 (02): : 115 - 120
  • [28] Antibacterial activity and mode of action of selected glucosinolate hydrolysis products against bacterial pathogens
    Anabela Borges
    Ana C. Abreu
    Carla Ferreira
    Maria J. Saavedra
    Lúcia C. Simões
    Manuel Simões
    Journal of Food Science and Technology, 2015, 52 : 4737 - 4748
  • [29] Antibacterial activity of siderophores from marine actinobacteria against Gram negative bacterial pathogens
    Ayswarya, S.
    Manigundan, K.
    Vijayalakshmi, G.
    Radhakrishnan, M.
    JOURNAL OF ENVIRONMENTAL BIOLOGY, 2022, 43 (02): : 223 - 230
  • [30] Antibacterial activity of a short de novo designed peptide against fish bacterial pathogens
    Bhat, Raja Aadil Hussain
    Khangembam, Victoria C.
    Pant, Vinita
    Tandel, Ritesh Shantilal
    Pandey, Pramod Kumar
    Thakuria, Dimpal
    AMINO ACIDS, 2024, 56 (01)
12345