Antibacterial activity of novel bacterial topoisomerase inhibitors against key veterinary pathogens

被引：0
|
作者：
Phelps, Hilary A. [1 ]
Kuhn, Michael [1 ]
Lu, Yanran [2 ]
Vibhute, Sandip [2 ,4 ]
Watts, Jeffrey L. [1 ]
Mitton-Fry, Mark J. [2 ,3 ]
机构：
[1] Zoetis, Global Therapeut, Anti Infect Res, 333 Portage St, Kalamazoo, MI 49007 USA
[2] Ohio State Univ, Coll Pharm, Div Med Chem & Pharmacognosy, 500 West 12th Ave, Columbus, OH 43210 USA
[3] 500 West 12th Ave, Columbus, OH 43210 USA
[4] Ohio State Univ, Comprehens Canc Ctr, Columbus, OH 43210 USA
来源：
VETERINARY MICROBIOLOGY | 2023年 / 284卷
关键词：
Antagonists & amp; Inhibitors; Mastitis; Staphylococcus; ANTIMICROBIAL RESISTANCE; MASTITIS;
D O I：
10.1016/j.vetmic.2023.109840
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Multidrug-resistant bacteria infect companion animals and livestock in addition to their devastating impact on human health. Novel Bacterial Topoisomerase Inhibitors (NBTIs) with excellent activity against Gram-positive bacteria have previously been identified as promising new antibacterial agents. Herein, we evaluate the antibacterial activity of these NBTIs against a variety of important veterinary pathogens and demonstrate outstanding in vitro activity, especially against staphylococci.
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页数：5
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