Staphylococcal biofilm: penetration and bioavailability of vancomycin with or without rifampin

被引：0

作者：

Daffinee, Kathryn E. ^{[1
]}

O'Neill, Emily T. ^{[1
,2
]}

Bleick, Callan R. ^{[2
]}

Williams, Geoff ^{[3
]}

Antoci, Valentin ^{[4
,5
]}

Garcia, Dioscaris ^{[4
,5
]}

LaPlante, Kerry L. ^{[1
,2
,6
]}

机构：

[1] Providence Vet Affairs Med Ctr, Infect Dis Res Program, Providence, RI 02908 USA

[2] Univ Rhode Isl, Coll Pharm, 02881, Ri, Kingston, Jamaica

[3] Brown Univ, Leduc Bioimaging Facil, Div Biol & Med, Providence, RI USA

[4] Brown Univ, Warren Alpert Sch Med, Dept Orthopaed, Providence, RI USA

[5] Rhode Isl Hosp, Diane N Weiss Ctr Orthopaed Trauma Res, Providence, RI USA

[6] Brown Univ, Warren Alpert Med Sch, Div Infect Dis, Providence, RI 02912 USA

来源：

DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE | 2023年 / 106卷 / 03期

关键词：

Staphylococcus epidermidis; Biofilm; Vancomycin; Rifampin; Microscopy; AUREUS BACTEREMIA; EPIDERMIDIS; DAPTOMYCIN; THERAPY;

D O I：

10.1016/j.diagmicrobio.2023.115947

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

We measured antibiotic penetration and bioavailability in staphylococcus biofilms using simulated human-ized concentrations of fluorescent vancomycin plus or minus rifampin. Vancomycin percent recovery across biofilm layers was:upper = 46%, middle = 40%, and lower = 33%. Vancomycin plus rifampin was not signifi-cantly different (P = 0.65). Addition of rifampin did not improve vancomycin penetration across biofilm layers.Published by Elsevier Inc.

引用

页数：3

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