Spinocerebellar ataxia type 1: It's not just about Purkinje cells

被引：0

作者：

Opal, Puneet ^{[1
,2
]}

机构：

[1] Northwestern Univ Feinberg Sch Med, Davee Dept Neurol, Chicago, IL 60611 USA

[2] Northwestern Univ, Dept Cell & Dev Biol, Feinberg Sch Med, Chicago, IL 60611 USA

来源：

NEURON | 2023年 / 111卷 / 16期

关键词：

D O I：

10.1016/j.neuron.2023.07.014

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

In this issue of Neuron, Pilotto et al.(1) use state-of-the-art in vivo imaging in mice to show that excitatory/inhibitory imbalance drives SCA1 pathophysiology, with hyperexcitable molecular layer interneurons overinhibiting Purkinje cells, leading to hallmark neurodegeneration.

引用

页码：2461 / 2462

页数：2

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