Spinocerebellar ataxia type 1: It's not just about Purkinje cells

被引：0

作者：

Opal, Puneet ^{[1
,2
]}

机构：

[1] Northwestern Univ Feinberg Sch Med, Davee Dept Neurol, Chicago, IL 60611 USA

[2] Northwestern Univ, Dept Cell & Dev Biol, Feinberg Sch Med, Chicago, IL 60611 USA

来源：

NEURON | 2023年 / 111卷 / 16期

关键词：

D O I：

10.1016/j.neuron.2023.07.014

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

In this issue of Neuron, Pilotto et al.(1) use state-of-the-art in vivo imaging in mice to show that excitatory/inhibitory imbalance drives SCA1 pathophysiology, with hyperexcitable molecular layer interneurons overinhibiting Purkinje cells, leading to hallmark neurodegeneration.

引用

页码：2461 / 2462

页数：2

共 50 条

[21] Purkinje Neuron Atrophy in Spinocerebellar Ataxia Type 1 Represents a Compensatory Mechanism for Increased Membrane Excitability
Dell'Orco, James
Wasserman, Aaron
Chopra, Ravi
Shakkottai, Vikram
ANNALS OF NEUROLOGY, 2014, 76 : S47 - S47
[22] The molecular diagnosis of spinocerebellar ataxia type 1 in patients with ataxia
Koefoed, P
Nielsen, JE
Hasholt, L
Jensen, PKA
Fenger, K
Sorensen, SA
EUROPEAN JOURNAL OF NEUROLOGY, 1997, 4 (06) : 586 - 592
[23] Properties of human Cav2.1 channel with a spinocerebellar ataxia type 6 mutation expressed in Purkinje cells
Saegusa, Hironao
Wakamori, Minoru
Matsuda, Yoshihiro
Wang, Junyang
Mori, Yasuo
Zong, Shuqin
Tanabe, Tsutomu
MOLECULAR AND CELLULAR NEUROSCIENCE, 2007, 34 (02) : 261 - 270
[24] Therapeutic Strategies for Spinocerebellar Ataxia Type 1
Kerkhof, Laurie M. C.
van de Warrenburg, Bart P. C.
van Roon-Mom, Willeke M. C.
Buijsen, Ronald A. M.
BIOMOLECULES, 2023, 13 (05)
[25] Molecular Mechanisms of Spinocerebellar Ataxia Type 1
Volovikov, E. A.
Davidenko, A. V.
Lagarkova, M. A.
RUSSIAN JOURNAL OF GENETICS, 2020, 56 (02) : 129 - 141
[26] Molecular Mechanisms of Spinocerebellar Ataxia Type 1
E. A. Volovikov
A. V. Davidenko
M. A. Lagarkova
Russian Journal of Genetics, 2020, 56 : 129 - 141
[27] Phenotypic variability of spinocerebellar ataxia type 1
Platonov, F. A.
Vladimirtsev, V. A.
Osakovskiy, V. L.
Goldfarb, L. G.
Gogolev, M. P.
EUROPEAN JOURNAL OF NEUROLOGY, 2004, 11 : 298 - 298
[28] Nuclear inclusions in spinocerebellar ataxia type 1
C. Duyckaerts
A. Dürr
G. Cancel
A. Brice
Acta Neuropathologica, 1999, 97 : 201 - 207
[29] Chronic suppression of STIM1-mediated calcium signaling in Purkinje cells rescues the cerebellar pathology in spinocerebellar ataxia type 2
Egorova, Polina A.
Marinina, Ksenia S.
Bezprozvanny, Ilya B.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH, 2023, 1870 (05):
[30] Nuclear inclusions in spinocerebellar ataxia type 1
Duyckaerts, C
Dürr, A
Cancel, G
Brice, A
ACTA NEUROPATHOLOGICA, 1999, 97 (02) : 201 - 207

← 1 2 3 4 5 →