Tumor-reactive T helper cells in the context of vaccination against glioma

被引：3
|
作者：
Zhao, Binghao [1 ,2 ,5 ]
Kilian, Michael [1 ,2 ,5 ]
Bunse, Theresa [1 ,2 ,5 ]
Platten, Michael [1 ,2 ,3 ,4 ,5 ,6 ,7 ]
Bunse, Lukas [1 ,2 ,3 ,5 ]
机构：
[1] German Canc Res Ctr, CCU Neuroimmunol & Brain Tumor Immunol, Heidelberg, Germany
[2] Heidelberg Univ, Med Fac Mannheim, Mannheim Ctr Translat Neurosci, Dept Neurol, Mannheim, Germany
[3] Univ Med Ctr Mannheim, DKFZ Hector Canc Inst, Mannheim, Germany
[4] DKFZ, Helmholtz Inst Translat Oncol Mainz Hitron Mainz H, Mainz, Germany
[5] German Canc Consortium DKTK, DKFZ, Core Ctr, Heidelberg, Germany
[6] DKFZ, Natl Ctr Tumor Dis NCT, Immune Monitoring Unit, Heidelberg, Germany
[7] Univ Hosp, Natl Ctr Tumor Dis NCT, Immune Monitoring Unit, Heidelberg, Germany
来源：
CANCER CELL | 2023年 / 41卷 / 11期
关键词：
D O I：
10.1016/j.ccell.2023.09.013
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
With the advances in immunogenomics, the majority of tumor-specific antigens were found to be recognized by T helper cells (THCs). This observation led to the development of long epitope vaccines in various cancers. Mechanistically, we are still gaining a deeper understanding of the mode of action of THCs as precision anti-tumor agonists. Here, we discuss the specific cellular mechanisms of THC functions in glioma immunology and contextualize current advances in anti-glioma vaccination exploiting THCs.
引用
收藏
页码：1829 / 1834
页数：6
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