Tumor-reactive T helper cells in the context of vaccination against glioma

被引：3

作者：

Zhao, Binghao ^{[1
,2
,5
]}

Kilian, Michael ^{[1
,2
,5
]}

Bunse, Theresa ^{[1
,2
,5
]}

Platten, Michael ^{[1
,2
,3
,4
,5
,6
,7
]}

Bunse, Lukas ^{[1
,2
,3
,5
]}

机构：

[1] German Canc Res Ctr, CCU Neuroimmunol & Brain Tumor Immunol, Heidelberg, Germany

[2] Heidelberg Univ, Med Fac Mannheim, Mannheim Ctr Translat Neurosci, Dept Neurol, Mannheim, Germany

[3] Univ Med Ctr Mannheim, DKFZ Hector Canc Inst, Mannheim, Germany

[4] DKFZ, Helmholtz Inst Translat Oncol Mainz Hitron Mainz H, Mainz, Germany

[5] German Canc Consortium DKTK, DKFZ, Core Ctr, Heidelberg, Germany

[6] DKFZ, Natl Ctr Tumor Dis NCT, Immune Monitoring Unit, Heidelberg, Germany

[7] Univ Hosp, Natl Ctr Tumor Dis NCT, Immune Monitoring Unit, Heidelberg, Germany

来源：

CANCER CELL | 2023年 / 41卷 / 11期

关键词：

D O I：

10.1016/j.ccell.2023.09.013

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

With the advances in immunogenomics, the majority of tumor-specific antigens were found to be recognized by T helper cells (THCs). This observation led to the development of long epitope vaccines in various cancers. Mechanistically, we are still gaining a deeper understanding of the mode of action of THCs as precision anti-tumor agonists. Here, we discuss the specific cellular mechanisms of THC functions in glioma immunology and contextualize current advances in anti-glioma vaccination exploiting THCs.

引用

页码：1829 / 1834

页数：6

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