Highly Regioselective Synthesis of N-β-trifluoromethyl 2-pyridones via anti-Markovnikov Hydroamination of α-(trifluoromethyl)styrenes with 2-pyridones

被引：0
|
作者：
Zhang, Yi [1 ]
Sun, Zhudi [1 ]
He, Jingjing [1 ]
Deng, Yupian [1 ]
Liu, Ying [1 ]
Zheng, Pai [1 ]
Cao, Song [1 ,2 ]
机构：
[1] East China Univ Sci & Technol ECUST, Shanghai Key Lab Chem Biol, Sch Pharm, Shanghai 200237, Peoples R China
[2] Chinese Acad Sci, Shanghai Inst Organ Chem, Key Lab Organofluorine Chem, Shanghai 200032, Peoples R China
来源：
CHEMISTRY-AN ASIAN JOURNAL | 2023年 / 18卷 / 10期
关键词：
alpha-(trifluoromethyl)styrenes; hydroamination; N-beta-trifluoromethyl; 2-pyridones; regioselectivity; MIGRATORY REARRANGEMENT; SUBSTITUTED; 2-PYRIDONES; O-ALKYLATION; PYRIDONES; DISCOVERY; ALKENES; REGIO;
D O I：
10.1002/asia.202300144
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A novel and facile method for the synthesis of N-beta-CF3-substituted 2-pyridones via hydroamination of alpha-(trifluoromethyl)styrenes with 2-pyridones was described. The reaction proceeded smoothly at room temperature, affording a variety of N-(beta-trifluoromethyl-beta-arylethyl)pyridin-2(1H)-ones in moderate to good yields with excellent N-regioselectivity.
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页数：5
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