Highly Regioselective Synthesis of N-β-trifluoromethyl 2-pyridones via anti-Markovnikov Hydroamination of α-(trifluoromethyl)styrenes with 2-pyridones

被引：0

作者：

Zhang, Yi ^{[1
]}

Sun, Zhudi ^{[1
]}

He, Jingjing ^{[1
]}

Deng, Yupian ^{[1
]}

Liu, Ying ^{[1
]}

Zheng, Pai ^{[1
]}

Cao, Song ^{[1
,2
]}

机构：

[1] East China Univ Sci & Technol ECUST, Shanghai Key Lab Chem Biol, Sch Pharm, Shanghai 200237, Peoples R China

[2] Chinese Acad Sci, Shanghai Inst Organ Chem, Key Lab Organofluorine Chem, Shanghai 200032, Peoples R China

来源：

CHEMISTRY-AN ASIAN JOURNAL | 2023年 / 18卷 / 10期

关键词：

alpha-(trifluoromethyl)styrenes; hydroamination; N-beta-trifluoromethyl; 2-pyridones; regioselectivity; MIGRATORY REARRANGEMENT; SUBSTITUTED; 2-PYRIDONES; O-ALKYLATION; PYRIDONES; DISCOVERY; ALKENES; REGIO;

D O I：

10.1002/asia.202300144

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A novel and facile method for the synthesis of N-beta-CF3-substituted 2-pyridones via hydroamination of alpha-(trifluoromethyl)styrenes with 2-pyridones was described. The reaction proceeded smoothly at room temperature, affording a variety of N-(beta-trifluoromethyl-beta-arylethyl)pyridin-2(1H)-ones in moderate to good yields with excellent N-regioselectivity.

引用

页数：5

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