Glomerular Filtration Rate Measured Based on Iomeprol Clearance Assessed at CT Urography in Living Kidney Donor Candidates

被引:2
|
作者
Stehle, Thomas [1 ,2 ,3 ]
Wei, Felix [1 ,4 ]
Brabant, Severine [9 ]
Luciani, Alain [1 ,4 ]
Grimbert, Philippe [2 ,3 ]
Prie, Dominique [9 ,10 ]
Reizine, Edouard [1 ,4 ]
Durrbach, Antoine [2 ,3 ,11 ,12 ]
Mule, Sebastien [1 ,4 ]
Hulin, Anne [1 ,5 ]
Boueilh, Anna [1 ,2 ,3 ]
Blain, Maxime [1 ,2 ,4 ]
Champy, Cecile-Maud [1 ,6 ]
Ingels, Alexandre [1 ,6 ]
Matignon, Marie [1 ,3 ]
Brasseur, Paul [1 ,7 ,8 ]
Canoui-Poitrine, Florence [1 ,7 ,8 ]
Pigneur, Frederic [1 ,4 ]
机构
[1] Univ Paris Est Creteil, Inst Natl Sante & Rech Med INSERM U955, Inst Mondor Rech Biomed, Creteil, France
[2] Hop Univ Henri Mondor, AP HP, Serv Nephrol & Transplantat, Creteil, France
[3] Hop Univ Henri Mondor, AP HP, Federat Hosp Univ Innovat Therapy Immune Disorders, Creteil, France
[4] Hop Univ Henri Mondor, AP HP, Serv Imagerie Med, Creteil, France
[5] Hop Univ Henri Mondor, AP HP, Lab Pharmacol, Creteil, France
[6] Hop Univ Henri Mondor, AP HP, Serv Urol, Creteil, France
[7] Hop Univ Henri Mondor, AP HP, Serv Sante Publ, Creteil, France
[8] Hop Univ Henri Mondor, AP HP, Unite Rech Clin, Creteil, France
[9] Grp Hosp Necker Enfants Malad, AP HP, Serv Physiol & Explorat Fonct, Paris, France
[10] Univ Paris Cite, Fac Med, INSERM U1151, Paris, France
[11] Univ Paris Saclay, Fac Med, Orsay, France
[12] Inst Gustave Roussy, INSERM, UMR 1186, Villejuif, France
关键词
CREATININE CLEARANCE; SERUM CREATININE; PLASMA SAMPLE; GATES METHOD; EQUATION; PHARMACOKINETICS; VALIDATION; GFR;
D O I
10.1148/radiol.230567
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
Background: Estimating glomerular filtration rate (GFR) from serum creatinine can be inaccurate, and current procedures for measuring GFR are time-consuming and cumbersome. Purpose: To develop a method for measuring GFR based on iomeprol clearance assessed at CT urography in kidney donor candidates and compare this with iohexol clearance (reference standard for measuring GFR). Materials and Methods: This cross-sectional retrospective study included data from kidney donor candidates who underwent both iohexol clearance and CT urography between July 2016 and October 2022. CT -measured GFR was calculated as the iomeprol excretion rate in the urinary system between arterial and excretory phases (Hounsfield units times milliliters per minute) divided by a surrogate for serum iomeprol concentration in the aorta at the midpoint (in Hounsfield units). Performance of CT -measured GFR was assessed with use of mean bias (mean difference between CT -measured GFR and iohexol clearance), precision (the distance between quartile 1 and quartile 3 of the bias [quartile 3 minus quartile 1], with a small value indicating high precision), and accuracy (percentage of CT -measured GFR values falling within 10%, 20%, and 30% of iohexol clearance values). Intraobserver agreement was assessed for 30 randomly selected individuals with the Lin concordance correlation coefficient. Results: A total of 75 kidney donor candidates were included (mean age, 51 years +/- 13 [SD]; 45 female). The CT -measured GFR was unbiased (1.1 mL/min/1.73 m2 [95% CI: -1.9, 4.1]) and highly precise (16.2 mL/min/1.73 m2 [quartiles 1 to 3, -6.6 to 9.6]). The accuracy of CT -measured GFR within 10%, 20%, and 30% was 61.3% (95% CI: 50.3, 72.4), 88.0% (95% CI: 80.7, 95.4), and 100%, respectively. Concordance between CT -based GFR measurements taken 2 months apart was almost perfect (correlation coefficient, 0.99 [95% CI: 0.98, 0.99]). Conclusion: In living kidney donors, GFR measured based on iomeprol clearance assessed at CT urography showed good agreement with GFR measured based on iohexol clearance. (c) RSNA, 2023
引用
收藏
页数:9
相关论文
共 50 条
  • [31] Effects of donor graft volume and measured glomerular filtration rate (GFR) on outcome of live donor kidney transplants
    Hila, S
    del Bosque, C
    Fatica, R
    Braun, W
    Herts, B
    Dennis, VW
    Poggio, ED
    AMERICAN JOURNAL OF TRANSPLANTATION, 2005, 5 : 531 - 531
  • [32] Glomerular filtration rate in prospective living kidney donors
    Glen M. Blake
    Christopher Sibley-Allen
    Rachel Hilton
    Lisa Burnapp
    Masood R. Moghul
    David Goldsmith
    International Urology and Nephrology, 2013, 45 : 1445 - 1452
  • [33] Glomerular filtration rate in prospective living kidney donors
    Blake, Glen M.
    Sibley-Allen, Christopher
    Hilton, Rachel
    Burnapp, Lisa
    Moghul, Masood R.
    Goldsmith, David
    INTERNATIONAL UROLOGY AND NEPHROLOGY, 2013, 45 (05) : 1445 - 1452
  • [34] Applicability of estimating glomerular filtration rate equations in pediatric patients: comparison with a measured glomerular filtration rate by iohexol clearance
    Deng, Fang
    Finer, Gal
    Haymond, Shannon
    Brooks, Ellen
    Langman, Craig B.
    TRANSLATIONAL RESEARCH, 2015, 165 (03) : 437 - 445
  • [35] DYNAMICS OF THE MEASURED GLOMERULA FILTRATION RATE FOR KIDNEY LIVING DONOR BEFORE AND AFTER THE DONATION
    Artinger, K.
    Knizacek, C.
    Hessl, A.
    Meinitzer, A.
    Zigeuner, R.
    Mueller, H.
    Kniepeiss, D.
    Mauric, A.
    Filipic, K.
    Rosenkranz, A. R.
    Zitta, S.
    TRANSPLANT INTERNATIONAL, 2016, 29 : 11 - 11
  • [36] Comparison cystatin C- and Creatinine- based estimated GFR with scintigraphy-measured glomerular filtration rate for living kidney donor evaluation
    Lerma, Vanessa
    TRANSPLANTATION, 2024, 108 (09) : 232 - 232
  • [37] Low absolute glomerular filtration rate in the living kidney donor -: A risk factor for graft loss
    Nordén, G
    Lennerling, A
    Nyberg, G
    TRANSPLANTATION, 2000, 70 (09) : 1360 - 1362
  • [38] Kidney Transplant Donor Glomerular Filtration Rate by lohexol Clearance During Computerized Tomographic Angiography of the Kidneys
    Hu, S. L.
    Igari, M.
    Walle, N. L.
    Steffes, M. W.
    Beland, M. D.
    Collins, S. A.
    Gohh, R. Y.
    TRANSPLANTATION PROCEEDINGS, 2013, 45 (09) : 3229 - 3233
  • [39] Comparison cystatin C- and Creatinine- based estimated GFR with scintigraphy-measured glomerular filtration rate for living kidney donor evaluation.
    Lerma, Vanessa
    TRANSPLANTATION, 2024, 108 (9S)
  • [40] Comparison of Kidney Volume-Based Methodology to Glomerular Filtration Rate Estimating Equations to Predict Measured Glomerular Filtration Rate in Cancer Patients
    Bezerra, Regis F.
    Dantas, Patricia P.
    Freire, Filipe D.
    Sapienza, Marcelo T.
    Levey, Andrew S.
    Inker, Lesley A.
    Costa e Silva, Veronica T.
    JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2021, 32 (10): : 580 - 581