The STING-mediated antiviral effect of fucoidan from Durvillaea antarctica

被引：2
|
作者：
Li, Zhaohe [1 ]
Li, Li [2 ]
Cai, Siqi [1 ]
Xu, Xiaohan [1 ]
Zhang, Xue [1 ]
Du, Kaixin [1 ]
Wei, Bo [1 ]
Wang, Xin [1 ,3 ]
Zhao, Xia [1 ,3 ]
Han, Wenwei [1 ,4 ]
机构：
[1] Ocean Univ China, Sch Med & Pharm, Key Lab Marine Drugs, Minist Educ, Qingdao 266003, Peoples R China
[2] Hainan Univ, Sch Pharm, Haikou 570228, Peoples R China
[3] Marine Biomed Res Inst Qingdao, Qingdao 266071, Peoples R China
[4] Univ Hlth & Rehabil Sci, Qingdao Hosp, Qingdao Municipal Hosp, Qingdao 266071, Peoples R China
来源：
CARBOHYDRATE POLYMERS | 2024年 / 331卷
基金：
中国国家自然科学基金;
关键词：
Fucoidan; Antiviral effect; Innate immunity; IFN-I; STING; SULFATED POLYSACCHARIDES; UNDARIA-PINNATIFIDA; ACTIVATION; INDUCTION; CELLS;
D O I：
10.1016/j.carbpol.2024.121899
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
Fucoidans have attracted increasing attention due to their minimal toxicity and various biological activities, such as antioxidant, anti-inflammatory, anti-tumor and immunomodulatory effects. In this study, the antiviral effect and mechanism of fucoidan (FU) derived from Durvillaea antarctica were explored in vitro. The results demonstrated that FU effectively inhibited the infection of both RNA virus (VSV) and DNA virus (HSV-1). The potential antiviral mechanism of FU is to trigger the production of type I IFN (IFN-I) and IFN-stimulated genes dependent on the cytoplasmic DNA adaptor STING (stimulator of interferon genes), and to enhance innate immune response via activating the STING-TBK1-IRF3 pathway. FU possesses the potential to be an antiviral and immunomodulatory agent in the future.
引用
收藏
页数：10
相关论文
共 50 条
  • [41] Polysaccharide nanoadjuvants with precise drug composition for enhanced STING-mediated APC activation
    Ju, Jingxuan
    Xu, Danni
    Xu, Li
    Liu, Jun
    Zeng, Hairong
    Zhao, Bei
    Xiong, Yuan
    Ma, Yuhui
    Ge, Guangbo
    Deng, Hongping
    EUROPEAN POLYMER JOURNAL, 2024, 217
  • [42] AdrA as a potential immunomodulatory candidate for STING-mediated anti-viral therapy
    Rodriguez, E.
    Zabaleta, N.
    Gil-Farina, I.
    Gonzalez-Aparicio, M.
    Solano, C.
    Lasa, I.
    Hommel, M.
    Gonzalez-Aseguinolaza, G.
    HUMAN GENE THERAPY, 2019, 30 (11) : A219 - A220
  • [43] Polysaccharide nanoadjuvants with precise drug composition for enhanced STING-mediated APC activation
    Ju, Jingxuan
    Xu, Danni
    Xu, Li
    Liu, Jun
    Zeng, Hairong
    Zhao, Bei
    Xiong, Yuan
    Ma, Yuhui
    Ge, Guangbo
    Deng, Hongping
    European Polymer Journal, 2024, 217
  • [44] Carnosic Acid Directly Targets STING C-Terminal Tail to Improve STING-Mediated Inflammatory Diseases
    Mu, Wenqing
    Xu, Guang
    Li, Ling
    Wen, Jincai
    Xiu, Ye
    Zhao, Jia
    Liu, Tingting
    Wei, Ziying
    Luo, Wei
    Yang, Huijie
    Wu, Zhixin
    Zhan, Xiaoyan
    Xiao, Xiaohe
    Bai, Zhaofang
    ADVANCED SCIENCE, 2025,
  • [45] STING-Mediated DNA Sensing Promotes Antitumor and Autoimmune Responses to Dying Cells
    Klarquist, Jared
    Hennies, Cassandra M.
    Lehn, Maria A.
    Reboulet, Rachel A.
    Feau, Sonia
    Janssen, Edith M.
    JOURNAL OF IMMUNOLOGY, 2014, 193 (12): : 6124 - 6134
  • [46] Discovery of an Orally Bioavailable STING Inhibitor with In Vivo Anti-Inflammatory Activity in Mice with STING-Mediated Inflammation
    Han, Xi
    Ma, Guangcai
    Peng, Ruikun
    Xu, Ju
    Sheng, Lixin
    Liu, Haohao
    Sui, Qibang
    Li, Jiaxin
    Gu, Yuhao
    Yu, Jinli
    Feng, Zhiqi
    Xu, Qinglong
    Wen, Xiaoan
    Yuan, Haoliang
    Sun, Hongbin
    Dai, Liang
    JOURNAL OF MEDICINAL CHEMISTRY, 2025, 68 (03) : 2963 - 2980
  • [47] Vinylphosphonate-based cyclic dinucleotides enhance STING-mediated cancer immunotherapy
    Dejmek, Milan
    Brazdova, Andrea
    Otava, Tomas
    Polidarova, Marketa Pimkova
    Klima, Martin
    Smola, Miroslav
    Vavrina, Zdenek
    Budesinsky, Milos
    Dracinsky, Martin
    Liboska, Radek
    Boura, Evzen
    Birkus, Gabriel
    Nencka, Radim
    EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2023, 259
  • [48] STING-mediated ferritinophagy drives ferroptosis in sepsis-induced intestinal injury
    Wu, Jie
    Liu, Qinjie
    Wu, Xiuwen
    Zhao, Yun
    Ren, Jianan
    FREE RADICAL BIOLOGY AND MEDICINE, 2022, 180 : 88 - 88
  • [49] STING-mediated DNA damage response in diabetes-induced vascular complications
    Bavuu, O.
    Pham, P. T.
    Sata, M.
    Fukuda, D.
    EUROPEAN HEART JOURNAL, 2024, 45
  • [50] TMEM203 is a binding partner and regulator of STING-mediated inflammatory signaling in macrophages
    Li, Yang
    James, Sharmy J.
    Wyllie, David H.
    Wynne, Claire
    Czibula, Agnes
    Bukhari, Ahmed
    Pye, Katherine
    Mustafah, Seri Musfirah Bte
    Fajka-Boja, Roberta
    Szabo, Eniko
    Angyal, Adrienn
    Hegedus, Zoltan
    Kovacs, Laszlo
    Hill, Adrian V. S.
    Jefferies, Caroline A.
    Wilson, Heather L.
    Zhang Yongliang
    Kiss-Toth, Endre
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2019, 116 (33) : 16479 - 16488
12345