The STING-mediated antiviral effect of fucoidan from Durvillaea antarctica

被引：2
|
作者：
Li, Zhaohe [1 ]
Li, Li [2 ]
Cai, Siqi [1 ]
Xu, Xiaohan [1 ]
Zhang, Xue [1 ]
Du, Kaixin [1 ]
Wei, Bo [1 ]
Wang, Xin [1 ,3 ]
Zhao, Xia [1 ,3 ]
Han, Wenwei [1 ,4 ]
机构：
[1] Ocean Univ China, Sch Med & Pharm, Key Lab Marine Drugs, Minist Educ, Qingdao 266003, Peoples R China
[2] Hainan Univ, Sch Pharm, Haikou 570228, Peoples R China
[3] Marine Biomed Res Inst Qingdao, Qingdao 266071, Peoples R China
[4] Univ Hlth & Rehabil Sci, Qingdao Hosp, Qingdao Municipal Hosp, Qingdao 266071, Peoples R China
来源：
CARBOHYDRATE POLYMERS | 2024年 / 331卷
基金：
中国国家自然科学基金;
关键词：
Fucoidan; Antiviral effect; Innate immunity; IFN-I; STING; SULFATED POLYSACCHARIDES; UNDARIA-PINNATIFIDA; ACTIVATION; INDUCTION; CELLS;
D O I：
10.1016/j.carbpol.2024.121899
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
Fucoidans have attracted increasing attention due to their minimal toxicity and various biological activities, such as antioxidant, anti-inflammatory, anti-tumor and immunomodulatory effects. In this study, the antiviral effect and mechanism of fucoidan (FU) derived from Durvillaea antarctica were explored in vitro. The results demonstrated that FU effectively inhibited the infection of both RNA virus (VSV) and DNA virus (HSV-1). The potential antiviral mechanism of FU is to trigger the production of type I IFN (IFN-I) and IFN-stimulated genes dependent on the cytoplasmic DNA adaptor STING (stimulator of interferon genes), and to enhance innate immune response via activating the STING-TBK1-IRF3 pathway. FU possesses the potential to be an antiviral and immunomodulatory agent in the future.
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页数：10
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