Oxyresveratrol Improves Cognitive Impairments and Episodic-like Memory through Modulating Neuroinflammation and PI3K-Akt Signaling Pathway in LPS-Induced Mice

被引：6

作者：

Yin, Guangling ^{[1
,2
]}

Pan, Chunxing ^{[1
]}

Liu, Hong ^{[3
]}

Dong, Changzhi ^{[1
]}

Chang, Xia ^{[1
]}

Zhou, Wei ^{[1
]}

Wang, Shanshan ^{[1
]}

Du, Zhiyun ^{[1
,4
]}

机构：

[1] Guangdong Univ Technol, Sch Biomed & Pharmaceut Sci, Guangzhou 510006, Peoples R China

[2] Byhealth Co Ltd, Guangzhou 510030, Peoples R China

[3] Jihua Lab, Foshan 528061, Peoples R China

[4] Foshan Allan Conney Biotechnol Co Ltd, Foshan 523281, Peoples R China

来源：

MOLECULES | 2024年 / 29卷 / 06期

关键词：

oxyresveratrol; cognitive impairments; memory; polarization; PI3K-Akt; MICROGLIA; POLARIZATION; SYSTEM;

D O I：

10.3390/molecules29061272

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Oxyresveratrol is one of the active ingredients derived from mulberry branch with strong anti-inflammatory bioactivity. In this research, we want to explore if oxyresveratrol can improve cognitive impairments and episodic-like memory and its mechanism. In LPS-induced BV-2 cells, 25 mu M OXY can significantly inhibit the expression of NO and alter the M1/M2 polarization by regulating M1/M2 phenotype makers. In vivo, OXY (50, 100 mg/kg) significantly reversed cognitive impairments and alleviated neuronal injuries caused by neuroinflammation. According to network pharmacology analysis, OXY alleviated neuroinflammation via the PI3K-Akt pathway. In general, the research revealed that OXY can improve cognitive impairments and episodic-like memory through alleviating LPS-induced neuroinflammation and regulating the PI3K-Akt signaling pathway.

引用

页数：16

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