Oxyresveratrol Improves Cognitive Impairments and Episodic-like Memory through Modulating Neuroinflammation and PI3K-Akt Signaling Pathway in LPS-Induced Mice

被引：6
|
作者：
Yin, Guangling [1 ,2 ]
Pan, Chunxing [1 ]
Liu, Hong [3 ]
Dong, Changzhi [1 ]
Chang, Xia [1 ]
Zhou, Wei [1 ]
Wang, Shanshan [1 ]
Du, Zhiyun [1 ,4 ]
机构：
[1] Guangdong Univ Technol, Sch Biomed & Pharmaceut Sci, Guangzhou 510006, Peoples R China
[2] Byhealth Co Ltd, Guangzhou 510030, Peoples R China
[3] Jihua Lab, Foshan 528061, Peoples R China
[4] Foshan Allan Conney Biotechnol Co Ltd, Foshan 523281, Peoples R China
来源：
MOLECULES | 2024年 / 29卷 / 06期
关键词：
oxyresveratrol; cognitive impairments; memory; polarization; PI3K-Akt; MICROGLIA; POLARIZATION; SYSTEM;
D O I：
10.3390/molecules29061272
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Oxyresveratrol is one of the active ingredients derived from mulberry branch with strong anti-inflammatory bioactivity. In this research, we want to explore if oxyresveratrol can improve cognitive impairments and episodic-like memory and its mechanism. In LPS-induced BV-2 cells, 25 mu M OXY can significantly inhibit the expression of NO and alter the M1/M2 polarization by regulating M1/M2 phenotype makers. In vivo, OXY (50, 100 mg/kg) significantly reversed cognitive impairments and alleviated neuronal injuries caused by neuroinflammation. According to network pharmacology analysis, OXY alleviated neuroinflammation via the PI3K-Akt pathway. In general, the research revealed that OXY can improve cognitive impairments and episodic-like memory through alleviating LPS-induced neuroinflammation and regulating the PI3K-Akt signaling pathway.
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页数：16
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