A hemicyanine-based fluorescent probe for ratiometric detection of ClO-and turn-on detection of viscosity and its imaging application in mitochondria of living cells and zebrafish

被引：60

作者：

Xu, Si-Lin ^{[1
]}

Guo, Fang-Fang ^{[2
]}

Xu, Zhi-Hong ^{[1
,3
]}

Wang, Yuan ^{[2
]}

James, Tony D. ^{[4
,5
]}

机构：

[1] Xuchang Univ, Key Lab Chemo Biosensing & Detect, Xuchang 461000, Peoples R China

[2] Henan Polytech Univ, Coll Chem & Chem Engn, Henan Key Lab Coal Green Convers, Jiaozuo 454000, Peoples R China

[3] Zhengzhou Univ, Coll Chem, Zhengzhou 450052, Peoples R China

[4] Univ Bath, Dept Chem, Bath BA2 7AY, England

[5] Henan Normal Univ, Sch Chem & Chem Engn, Xinxiang 453007, Peoples R China

来源：

SENSORS AND ACTUATORS B-CHEMICAL | 2023年 / 383卷

基金：

中国国家自然科学基金;

关键词：

Fluorescent probe; Imaging; Hypochlorite; Mitochondria targeting; Viscosity; HYPOCHLORITE;

D O I：

10.1016/j.snb.2023.133510

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A water-soluble fluorescent probe 1 based on chromene-hemicyanine has been developed, that exhibits ratio -metric fluorescent response toward hypochlorite (ClO-) with the LOD (0.082 mu M), and "turn-on" response to viscosity changes. Due to low cytotoxicity and good biocompatibility, probe 1 used to monitor hypochlorous acid and viscosity in mitochondria of living cells and zebrafish.

引用

页数：9

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