A hemicyanine-based fluorescent probe for ratiometric detection of ClO-and turn-on detection of viscosity and its imaging application in mitochondria of living cells and zebrafish

被引：60
|
作者：
Xu, Si-Lin [1 ]
Guo, Fang-Fang [2 ]
Xu, Zhi-Hong [1 ,3 ]
Wang, Yuan [2 ]
James, Tony D. [4 ,5 ]
机构：
[1] Xuchang Univ, Key Lab Chemo Biosensing & Detect, Xuchang 461000, Peoples R China
[2] Henan Polytech Univ, Coll Chem & Chem Engn, Henan Key Lab Coal Green Convers, Jiaozuo 454000, Peoples R China
[3] Zhengzhou Univ, Coll Chem, Zhengzhou 450052, Peoples R China
[4] Univ Bath, Dept Chem, Bath BA2 7AY, England
[5] Henan Normal Univ, Sch Chem & Chem Engn, Xinxiang 453007, Peoples R China
来源：
SENSORS AND ACTUATORS B-CHEMICAL | 2023年 / 383卷
基金：
中国国家自然科学基金;
关键词：
Fluorescent probe; Imaging; Hypochlorite; Mitochondria targeting; Viscosity; HYPOCHLORITE;
D O I：
10.1016/j.snb.2023.133510
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
A water-soluble fluorescent probe 1 based on chromene-hemicyanine has been developed, that exhibits ratio -metric fluorescent response toward hypochlorite (ClO-) with the LOD (0.082 mu M), and "turn-on" response to viscosity changes. Due to low cytotoxicity and good biocompatibility, probe 1 used to monitor hypochlorous acid and viscosity in mitochondria of living cells and zebrafish.
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页数：9
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