Synthesis of Indolo[2,1-a]isoquinolines by Nickel-Catalyzed Mizoroki-Heck/Amination Cascade Reaction

被引：7
|
作者：
Wu, Chaoyi [1 ,2 ,3 ]
Lin, Jin [1 ,2 ,3 ]
Tian, Xu [1 ,2 ,3 ]
机构：
[1] Guangzhou Med Univ, Guangzhou Municipal & Guangdong Prov Key Lab Mol T, NMPA, Guangzhou 511436, Guangdong, Peoples R China
[2] Guangzhou Med Univ, Sch Pharmaceut Sci, State Key Lab Resp Dis, Guangzhou 511436, Guangdong, Peoples R China
[3] Guangzhou Med Univ, Affiliated Hosp 5, Guangzhou 511436, Guangdong, Peoples R China
来源：
ORGANIC LETTERS | 2023年 / 25卷 / 01期
关键词：
RECEPTOR-BINDING AFFINITIES; C-H; COUPLING REACTIONS; HECK; ARYL; HETEROCYCLES; AMINATION; INDOLES; ARYLATION; INVERSION;
D O I：
10.1021/acs.orglett.2c03973
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An efficient Mizoroki-Heck/amination cascade reaction of o-dihaloarenes with cyclic imines was realized by combining nickel and a sterically bulky N-heterocyclic carbene ligand. This protocol provides access to a variety of indole[2,1-a]isoquinolines from readily available starting materials. This cascade approach could be applied to produce straightforward synthesis of the natural product cryptowoline.
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页码：158 / 162
页数：5
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