Synthesis of Indolo[2,1-a]isoquinolines by Nickel-Catalyzed Mizoroki-Heck/Amination Cascade Reaction

被引：7

作者：

Wu, Chaoyi ^{[1
,2
,3
]}

Lin, Jin ^{[1
,2
,3
]}

Tian, Xu ^{[1
,2
,3
]}

机构：

[1] Guangzhou Med Univ, Guangzhou Municipal & Guangdong Prov Key Lab Mol T, NMPA, Guangzhou 511436, Guangdong, Peoples R China

[2] Guangzhou Med Univ, Sch Pharmaceut Sci, State Key Lab Resp Dis, Guangzhou 511436, Guangdong, Peoples R China

[3] Guangzhou Med Univ, Affiliated Hosp 5, Guangzhou 511436, Guangdong, Peoples R China

来源：

ORGANIC LETTERS | 2023年 / 25卷 / 01期

关键词：

RECEPTOR-BINDING AFFINITIES; C-H; COUPLING REACTIONS; HECK; ARYL; HETEROCYCLES; AMINATION; INDOLES; ARYLATION; INVERSION;

D O I：

10.1021/acs.orglett.2c03973

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient Mizoroki-Heck/amination cascade reaction of o-dihaloarenes with cyclic imines was realized by combining nickel and a sterically bulky N-heterocyclic carbene ligand. This protocol provides access to a variety of indole[2,1-a]isoquinolines from readily available starting materials. This cascade approach could be applied to produce straightforward synthesis of the natural product cryptowoline.

引用

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页码：158 / 162

页数：5

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