Safety and Feasibility of Riociguat Therapy for the Treatment of Chronic Pulmonary Arterial Hypertension in Infancy

被引：8
|
作者：
Giesinger, Regan E. [1 ]
Stanford, Amy H. [1 ]
Thomas, Brady [1 ]
Abman, Steven H. [2 ]
McNamara, Patrick J. [1 ]
机构：
[1] Univ Iowa, Dept Pediat, Iowa City, IA USA
[2] Univ Colorado, Dept Pediat, Denver, CO USA
来源：
JOURNAL OF PEDIATRICS | 2023年 / 255卷
关键词：
SOLUBLE GUANYLATE-CYCLASE; BRONCHOPULMONARY DYSPLASIA; ECHOCARDIOGRAPHY; SILDENAFIL; DISEASE;
D O I：
10.1016/j.jpeds.2022.11.026
中图分类号：
R72 [儿科学];
学科分类号：
100202 ;
摘要：
The effects of riociguat, an oral-soluble guanylate-cyclase stimulator, were studied in 10 infants with chronic pulmonary arterial hypertension. Respiratory status (n = 8/10), right heart dilation (n = 7/10), function (n = 9/10), and chronic pulmonary arterial hypertension (n = 8/10) improved. Median decrement in systolic (12 [4, 14]), diastolic (14 [7, 20]), and mean arterial (14 [10, 17]) pressures were noted; no critical hypotension or hypoxemia occurred.
引用
收藏
页码：224 / +
页数：7
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