Safety and Feasibility of Riociguat Therapy for the Treatment of Chronic Pulmonary Arterial Hypertension in Infancy

被引：8

作者：

Giesinger, Regan E. ^{[1
]}

Stanford, Amy H. ^{[1
]}

Thomas, Brady ^{[1
]}

Abman, Steven H. ^{[2
]}

McNamara, Patrick J. ^{[1
]}

机构：

[1] Univ Iowa, Dept Pediat, Iowa City, IA USA

[2] Univ Colorado, Dept Pediat, Denver, CO USA

来源：

JOURNAL OF PEDIATRICS | 2023年 / 255卷

关键词：

SOLUBLE GUANYLATE-CYCLASE; BRONCHOPULMONARY DYSPLASIA; ECHOCARDIOGRAPHY; SILDENAFIL; DISEASE;

D O I：

10.1016/j.jpeds.2022.11.026

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

The effects of riociguat, an oral-soluble guanylate-cyclase stimulator, were studied in 10 infants with chronic pulmonary arterial hypertension. Respiratory status (n = 8/10), right heart dilation (n = 7/10), function (n = 9/10), and chronic pulmonary arterial hypertension (n = 8/10) improved. Median decrement in systolic (12 [4, 14]), diastolic (14 [7, 20]), and mean arterial (14 [10, 17]) pressures were noted; no critical hypotension or hypoxemia occurred.

引用

页码：224 / +

页数：7

共 50 条

[21] RIOCIGUAT IN THE PHARMACOLOGICAL TREATMENT OF PULMONARY ARTERIAL HYPERTENSION: A SYSTEMATIC REVIEW
Faria, G. G.
Mosegui, G. B.
Vianna, C. M.
Tavares, C., V
Cordeiro, B. C.
VALUE IN HEALTH, 2017, 20 (05) : A200 - A200
[22] Riociguat treatment in patients with pulmonary arterial hypertension: Final safety data from the EXPERT registry
Hoeper, Marius M.
Gomez Sanchez, Miguel-Angel
Humbert, Marc
Pittrow, David
Simonneau, Gerald
Gall, Henning
Gruenig, Ekkehard
Klose, Hans
Halank, Michael
Langleben, David
Snijder, Repke J.
Subias, Pilar Escribano
Mielniczuk, Lisa M.
Lange, Tobias J.
Vachiery, Jean-Luc
Wirtz, Hubert
Helmersen, Douglas S.
Tsangaris, Iraklis
Barbera, Joan A.
Pepke-Zaba, Joanna
Boonstra, Anco
Rosenkranz, Stephan
Ulrich, Silvia
Steringer-Mascherbauer, Regina
Delcroix, Marion
Jansa, Pavel
Simkova, Iveta
Giannakoulas, George
Klotsche, Jens
Williams, Evgenia
Meier, Christian
Ghofrani, Hossein-Ardeschir
RESPIRATORY MEDICINE, 2021, 177
[23] Safety of Riociguat for the Treatment of Pulmonary Arterial Hypertension: Final Data Cut from the EXPERT Registry
Hoeper, M.
Gall, H.
Gruenig, E.
Klose, H.
Halank, M.
Langleben, D.
Snijder, R. J.
Escribano, P.
Mielniczuk, L. M.
Lange, T.
Vachiery, J. E.
Wirtz, H.
Helmersen, D. S.
Tsangaris, I.
Barbera, J. A.
Pepke-Zaba, J.
Boonstra, A.
Rosenkranz, S.
Ulrich, S.
Steringer-Mascherbauer, R.
Sanchez, M. A. Gomez
Humbert, M.
Pittrow, D.
Simonneau, G.
Klotsche, J.
Williams, E.
Meier, C.
Ghofrani, H. A.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2019, 199
[24] Individual dose adjustment of riociguat in patients with pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension
Hill, Nicholas S.
Rahaghi, Franck F.
Sood, Namita
Frey, Reiner
Ghofrani, Hossein-Ardeschir
RESPIRATORY MEDICINE, 2017, 129 : 124 - 129
[25] Riociguat therapy for pulmonary hypertension
Gregory B. Lim
Nature Reviews Cardiology, 2013, 10 (10) : 549 - 549
[26] Stability of Rapid Titration of Riociguat in Patients with Pulmonary Arterial Hypertension and Chronic Thromboembolic Pulmonary Hypertension
Katta, S.
Safdar, Z.
Sahay, S.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2020, 201
[27] Riociguat: A Review of Its Use in Patients with Chronic Thromboembolic Pulmonary Hypertension or Pulmonary Arterial Hypertension
Karly P. Garnock-Jones
Drugs, 2014, 74 : 2065 - 2078
[28] Riociguat: A Review of Its Use in Patients with Chronic Thromboembolic Pulmonary Hypertension or Pulmonary Arterial Hypertension
Garnock-Jones, Karly P.
DRUGS, 2014, 74 (17) : 2065 - 2078
[29] MEDICAL THERAPY FOR CHRONIC THROMBOEMBOLIC PULMONARY HYPERTENSION: AN INDIRECT TREATMENT COMPARISON OF MACITENTAN AND RIOCIGUAT
Di Scala, L.
Howard, L. S.
Jing, Z. C.
Lin, X.
Mayer, E.
Jenkins, D. P.
Kim, N. H.
VALUE IN HEALTH, 2019, 22 : S335 - S335
[30] Riociguat for treatment of pulmonary hypertension
Schermuly R.
Misselwitz F.
Tiede H.
Clinical Research in Cardiology Supplements, 2010, 5 (Suppl 2) : 16 - 18

← 1 2 3 4 5 →