Steroidal alkaloids from the bulbs of Fritillaria unibracteata var. wabuensis and their anti-inflammatory activities

被引：4

作者：

Wang, Shu-Hui ^{[1
]}

Wang, Yu-Qi ^{[1
]}

Wang, Qi-Qi ^{[1
]}

Wang, Le ^{[2
]}

Zhang, Qing-Ying ^{[1
]}

Tu, Peng-Fei ^{[1
]}

机构：

[1] Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China

[2] Minzu Univ China, Sch Pharm, Beijing 100081, Peoples R China

来源：

PHYTOCHEMISTRY | 2023年 / 209卷

关键词：

Fritillaria unibracteata var; Wabuensis (S; Y; tang & S; C; yueh) Z; Liu; Shu wang & S; chen; Liliaceae; Chuan bei-mu; Steroidal alkaloids; Anti-inflammation; ISOSTEROIDAL ALKALOIDS; VERATRUM; ELUCIDATION;

D O I：

10.1016/j.phytochem.2023.113640

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Fourteen previously undescribed steroidal alkaloids, including six jervine-type, wabujervine A-E and wabujerside A, seven cevanine-type, wabucevanine A-G, and one secolanidin-type, wabusesolanine A, along with thirteen known steroidal alkaloids, were isolated from the bulbs of Fritillaria unibracteata var. wabuensis. On the basis of comprehensive analysis of IR, HRESIMS, 1D and 2D NMR spectroscopic data, and single-crystal X-ray diffraction analyses, their structures were elucidated. In the zebrafish acute inflammatory models, nine compounds showed anti-inflammatory activity.

引用

页数：12

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