New steroidal alkaloids from Fritillaria imperialis and their cholinesterase inhibiting activities

被引：53
|
作者：
Atta-ur-Rahman
Akhtar, MN
Choudhary, MI [1 ]
Tsuda, Y
Sener, B
Khalid, A
Parvez, M
机构：
[1] Univ Karachi, Int Ctr Chem Sci, HEJ Res Inst Chem, Karachi 75270, Pakistan
[2] Gazi Univ, Fac Pharm, Dept Pharmacognosy, TR-06330 Ankara, Turkey
[3] Univ Calgary, Fac Sci, Dept Chem, Calgary, AB, Canada
来源：
CHEMICAL & PHARMACEUTICAL BULLETIN | 2002年 / 50卷 / 08期
关键词：
Fritillaria imperialis; impericine; forticine; cevanine-type; acetylcholinesterase; butyrylcholinesterase;
D O I：
10.1248/cpb.50.1013
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Two new cevanine steroidal alkaloids, impericine (1) and forticine (2) along with known bases delavine (3), persicanidine A (4), and imperialine (5) were isolated from the bulbs of Fritillaria imperialis. The structures of impericine (1) [(20R,22S,25S)-5alpha-cevanin-23-ene-3beta,6beta,16beta,8-triol] and forticine (2) [(20S,22S,25S)-5alpha-cevanine-3beta,6beta-diol] were determined with the help of spectroscopic studies. These steroidal bases showed anti-acetylcholinesterase and anti-butyrylcholinesterase inhibitory activity.
引用
收藏
页码：1013 / 1016
页数：4
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