Nano-quantum sensors-based imaging and sensing for target-based drug discovery and development

被引：1

作者：

Shimada, Taisuke ^{[1
]}

Ueda, Yasuyuki ^{[2
]}

Takemaru, Hikari ^{[2
,3
]}

Baba, Yoshinobu ^{[1
,2
,4
]}

Yukawa, Hiroshi ^{[2
,4
,5
,6
]}

机构：

[1] Nagoya Univ, Grad Sch Engn, Dept Biomol Engn, Furo Cho,Chikusa Ku, Nagoya 4648603, Japan

[2] Natl Inst Quantum Sci & Technol QST, Inst Quantum Life Sci, Anagawa 4-9-1,Inage Ku, Chiba 2638555, Japan

[3] Chiba Univ, Grad Sch Sci & Engn, Div Adv Sci & Engn, Inage Ku, 1-33 Yayoicho,Inage Ku, Chiba 2638522, Japan

[4] Nagoya Univ, Inst Nanolife Syst, Inst Innovat Future Soc, Furo Cho,Chikusa Ku, Nagoya 4648603, Japan

[5] Nagoya Univ, Inst Adv Res, Adv Analyt & Diagnost Imaging Ctr AADIC, Med Engn Unit MEU,B3 Unit, Tsurumai Cho 65,Showa Ku, Nagoya 4668550, Japan

[6] Nagoya Univ, Dev Quantum Nano Canc Photoimmunotherapy Clin Appl, Tsurumai 65,Showa Ku, Nagoya 4668550, Japan

来源：

TRAC-TRENDS IN ANALYTICAL CHEMISTRY | 2024年 / 171卷

关键词：

Nano -quantum sensor; Quantum dot; Fluorescent nanodiamond; Surface modification; Target specificity; Imaging; Sensing; Theranostics; PHOTOCHEMICAL MODIFICATION; FLUORESCENT NANODIAMONDS; STEM-CELLS; DOTS; SURFACE; FUNCTIONALIZATION; SEMICONDUCTOR; LIGANDS; NANOPARTICLES; NANOCRYSTALS;

D O I：

10.1016/j.trac.2023.117496

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Biological imaging and sensing are vital for understanding the biochemical and biological processes related to drug discovery and development. Nano-quantum sensors such as quantum dots and fluorescent nanodiamonds are luminescent nanoparticle sensors with excellent optical properties originating from quantum effects, and these sensors are promising for long-term imaging and physicochemical sensing with high spatiotemporal resolution. However, owing to the requirements of biological compatibility and target specificity for such sensor applications, modifying the sensor surfaces is essential. Moreover, owing to the demand for imaging- and sensing-assisted therapies (theranostics), a combination of nano-quantum sensors and therapeutic agents has been developed via surface modifications. We herein outline advanced surface modifications of nano-quantum sensors and their applications in in vitro and in vivo imaging, sensing, and therapy for target-based drug discovery and development.

引用

页数：12

共 50 条

[1] Target-based drug discovery for the development of novel antiinfectives
Selzer, PM
Brutsche, S
Wiesner, P
Schmid, P
Müllner, H
INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY, 2000, 290 (02) : 191 - 201
[2] Unfinished business: target-based drug discovery
Brown, David
DRUG DISCOVERY TODAY, 2007, 12 (23-24) : 1007 - 1012
[3] Future target-based drug discovery for tuberculosis?
Kana, Bavesh Davandra
Karakousis, Petros C.
Parish, Tanya
Dick, Thomas
TUBERCULOSIS, 2014, 94 (06) : 551 - 556
[4] Target-based drug discovery: is something wrong?
Sams-Dodd, F
DRUG DISCOVERY TODAY, 2005, 10 (02) : 139 - 147
[5] Navigating tuberculosis drug discovery with target-based screening
Miller, Christopher H.
O'Toole, Ronan F.
EXPERT OPINION ON DRUG DISCOVERY, 2011, 6 (08) : 839 - 854
[6] Target-based drug discovery for malaria, leishmaniasis, and trypanosomiasis
Werbovetz, KA
CURRENT MEDICINAL CHEMISTRY, 2000, 7 (08) : 835 - 860
[7] Phage display for target-based antibacterial drug discovery
Christensen, DJ
Gottlin, EB
Benson, RE
Hamilton, PT
DRUG DISCOVERY TODAY, 2001, 6 (14) : 721 - 727
[8] Target-based drug discovery, genetic diseases, and biologics
Hurko, Orest
NEUROCHEMISTRY INTERNATIONAL, 2012, 61 (06) : 892 - 898
[9] Solution NMR Spectroscopy in Target-Based Drug Discovery
Li, Yan
Kang, Congbao
MOLECULES, 2017, 22 (09)
[10] Surface plasmon resonance as a fascinating approach in target-based drug discovery and development
Das, Shibam
Singh, Sukhwinder
Chawla, Viney
Chawla, Pooja A.
Bhatia, Rohit
TRAC-TRENDS IN ANALYTICAL CHEMISTRY, 2024, 171

← 1 2 3 4 5 →