CDX model based genome-scale CRISPR KO screens for modulators of KRAS (G12C) inhibitor sensitivity

被引：0
|
作者：
Zhao, Haixin
Zhai, Fangzheng
Li, Bin
Fan, Qiangqiang
Peng, Zhengang
机构：
来源：
CANCER RESEARCH | 2023年 / 83卷 / 07期
关键词：
D O I：
10.1158/1538-7445.AM2023-257
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
257
引用
收藏
页数：2
相关论文
共 50 条
  • [41] A first-in-human phase 1 study of LY3537982, a novel, highly selective and potent KRAS G12C inhibitor in patients with KRAS G12C mutant advanced solid tumors (trial in progress).
    Ammakkanavar, Natraj Reddy
    Call, Justin
    Shimizu, Toshio
    Kuboki, Yasutoshi
    Liu, Shiyao
    Willard, Melinda D.
    Axelson, Michael
    Heist, Rebecca S.
    Patnaik, Amita
    CANCER RESEARCH, 2022, 82 (12)
  • [42] Optimization of intermittent dosing strategies of KRAS G12C inhibitors in preclinical lung cancer model
    Navarro, Valeria Estrada
    Panneton, Vincent
    Dong, Lauren
    Choi, Hyejin
    Venkatesh, Divya
    Maniyar, Rachana
    Schulze, Isabell
    Wolchok, Jedd D.
    Merghoub, Taha
    CANCER RESEARCH, 2024, 84 (06)
  • [43] Focal adhesive kinase inhibitor IN10018 sensitizes KRAS mutant cancer and overcomes drug resistance of KRAS G12C inhibition
    Zhang, Baoyuan
    Zhang, Yan
    Zhang, Jiangwei
    Liu, Ping
    Jiao, Bo
    Wang, Zaiqi
    Ren, Ruibao
    CANCER RESEARCH, 2020, 80 (16)
  • [44] An allosteric pan-TEAD inhibitor blocks oncogenic YAP/TAZ signaling and overcomes KRAS G12C inhibitor resistance
    Thijs J. Hagenbeek
    Jason R. Zbieg
    Marc Hafner
    Rana Mroue
    Jennifer A. Lacap
    Nicole M. Sodir
    Cameron L. Noland
    Shervin Afghani
    Ayush Kishore
    Kamakoti P. Bhat
    Xiaosai Yao
    Stephen Schmidt
    Saundra Clausen
    Micah Steffek
    Wendy Lee
    Paul Beroza
    Scott Martin
    Eva Lin
    Rina Fong
    Paola Di Lello
    Marta H. Kubala
    Michelle N.-Y. Yang
    Jeffrey T. Lau
    Emily Chan
    Alfonso Arrazate
    Le An
    Elizabeth Levy
    Maria N. Lorenzo
    Ho-June Lee
    Trang H. Pham
    Zora Modrusan
    Richard Zang
    Yi-Chen Chen
    Michal Kabza
    Musaddeque Ahmed
    Jason Li
    Matthew T. Chang
    Danilo Maddalo
    Marie Evangelista
    Xin Ye
    James J. Crawford
    Anwesha Dey
    Nature Cancer, 2023, 4 : 812 - 828
  • [45] Discovery of novel Quinazoline-based KRAS G12C inhibitors as potential anticancer agents
    Li, Ling
    Zhao, Huiting
    Peng, Xiaopeng
    Liu, Jin
    Mai, Ruiyao
    Chen, Jingxuan
    Lin, Lin
    Chen, Ting
    Yan, Jun
    Shi, Jiaolong
    Chen, Jianjun
    BIOORGANIC & MEDICINAL CHEMISTRY, 2022, 71
  • [46] An allosteric pan-TEAD inhibitor blocks oncogenic YAP/TAZ signaling and overcomes KRAS G12C inhibitor resistance
    Hagenbeek, Thijs J. J.
    Zbieg, Jason R. R.
    Hafner, Marc
    Mroue, Rana
    Lacap, Jennifer A. A.
    Sodir, Nicole M. M.
    Noland, Cameron L. L.
    Afghani, Shervin
    Kishore, Ayush
    Bhat, Kamakoti P. P.
    Yao, Xiaosai
    Schmidt, Stephen
    Clausen, Saundra
    Steffek, Micah
    Lee, Wendy
    Beroza, Paul
    Martin, Scott
    Lin, Eva
    Fong, Rina
    Di Lello, Paola
    Kubala, Marta H. H.
    Yang, Michelle N. -Y.
    Lau, Jeffrey T. T.
    Chan, Emily
    Arrazate, Alfonso
    An, Le
    Levy, Elizabeth
    Lorenzo, Maria N. N.
    Lee, Ho-June
    Pham, Trang H. H.
    Modrusan, Zora
    Zang, Richard
    Chen, Yi-Chen
    Kabza, Michal
    Ahmed, Musaddeque
    Li, Jason
    Chang, Matthew T. T.
    Maddalo, Danilo
    Evangelista, Marie
    Ye, Xin
    Crawford, James J. J.
    Dey, Anwesha
    NATURE CANCER, 2023, 4 (06) : 812 - +
  • [47] Adagrasib, a KRAS G12C inhibitor, reverses the multidrug resistance mediated by ABCB1 in vitro and in vivo
    Zhang, Yuchen
    Li, Cheukfai
    Xia, Chenglai
    To, Keneth Kin Wah
    Guo, Zhixing
    Ren, Chongyang
    Wen, Lingzhu
    Wang, Fang
    Fu, Liwu
    Liao, Ning
    CELL COMMUNICATION AND SIGNALING, 2022, 20 (01)
  • [48] Adagrasib, a KRAS G12C inhibitor, reverses the multidrug resistance mediated by ABCB1 in vitro and in vivo
    Yuchen Zhang
    Cheukfai Li
    Chenglai Xia
    Keneth Kin Wah To
    Zhixing Guo
    Chongyang Ren
    Lingzhu Wen
    Fang Wang
    Liwu Fu
    Ning Liao
    Cell Communication and Signaling, 20
  • [49] Development of a Streamlined Manufacturing Process for the Highly Substituted Quinazoline Core Present in KRAS G12C Inhibitor Divarasib
    Burkhard, Johannes A.
    Herold, Sebastian
    Leitner, Christian
    Zhang, Haiming
    Angelaud, Remy
    Tian, Qingping
    Han, Chong
    Gosselin, Francis
    ORGANIC PROCESS RESEARCH & DEVELOPMENT, 2024, 28 (01) : 102 - 111
  • [50] Remodeling of the tumor/tumor microenvironment ecosystem during KRAS G12C inhibitor clinical resistance in lung cancer
    Manabe, Tadashi
    Bivona, Trever G.
    JOURNAL OF CLINICAL INVESTIGATION, 2022, 132 (04):
12345