共 50 条
- [31] Discovery of Potent, Orally Bioavailable, Small-Molecule Inhibitors of WNT Signaling from a Cell-Based Pathway ScreenJOURNAL OF MEDICINAL CHEMISTRY, 2015, 58 (04) : 1717 - 1735Mallinger, AurelieCrumpler, SimonPichowicz, MarkWaalboer, DennisStubbs, MarkAdeniji-Popoola, OlajumokeWood, BozenaSmith, ElizabethThai, ChingHenley, Alan T.Georgi, KatrinCourt, WilliamHobbs, SteveBox, GaryOrtiz-Ruiz, Maria-JesusValenti, MelanieBrandon, Alexis De HavenTePoele, RobertLeuthner, BirgittaWorkman, PaulAherne, WynnePoeschke, OliverDale, TrevorWienke, DirkEsdar, ChristinaRohdich, FelixRaynaud, FlorenceClarke, Paul A.Eccles, Suzanne A.Stieber, FrankSchiemann, KaiBlagg, Julian
- [32] Discovery of GNE-6893, a Potent, Selective, Orally Bioavailable Small Molecule Inhibitor of HPK1ACS MEDICINAL CHEMISTRY LETTERS, 2024, 15 (09): : 1606 - 1614Tellis, John C.Wei, BinQingSiu, MichaelAn, LeChan, Grace KayanChen, YongDu, XiangnanGazzard, LewisHu, BaihuaKiefer, JamesKakiuchi-Kiyota, SatokoLainchbury, MichaelLinehan, Jonathan L.Luo, XifengMalhotra, SushantMendonca, RohanPang, JodieRan, YinqingSethuraman, VijaySeward, EileenSneeringer, ChrisSu, DianWang, WeiruWu, PingMoffat, John G.Heffron, Timothy P.Choo, Edna F.Chan, Bryan K.
- [33] Discovery of Orally Available and Brain Penetrant AEP InhibitorsJOURNAL OF MEDICINAL CHEMISTRY, 2023, 66 (24) : 17026 - 17043Krummenacher, DanielaHe, WeipingKuhn, BerndSchnider, ChristianBeurier, AngelicaBrom, VirginieSivasothy, ThulaseMarty, ChristineTosstorff, AndreasHewings, David S.Mesch, StefaniePinard, EmmanuelBrandlin, MathisHochstrasser, RemoWestwood, PaulRothe, JudithKronenberger, AlexandraMorandi, FedericaGutbier, SimonSchuler, AngelikaHeer, DominikGloria, Ludivine EstevesJoedicke, LisaRudolph, Markus G.Muller, LutzGruninger, FionaBaumann, KarlheinzKaniyappan, SenthilvelrajanManevski, NenadBartels, Bjorn
- [34] Discovery of Highly Potent, Selective, and Efficacious Small Molecule Inhibitors of ERK1/2JOURNAL OF MEDICINAL CHEMISTRY, 2015, 58 (04) : 1976 - 1991Ren, LiGrina, JonasMoreno, DavidBlake, James F.Gaudino, John J.Garrey, RustamMetcalf, Andrew T.Burkard, MichaelMartinson, MatthewRasor, KevinChen, HuifenDean, BrianGould, Stephen E.Pacheco, PatriciaShahidi-Latham, SheerinYin, JianpingWest, KristinaWang, WeiruMoffat, John G.Schwarz, Jacob B.
- [35] Discovery of small molecule inhibitors of the interaction between PPARγ and SMRTCANCER RESEARCH, 2014, 74 (19)Min, JaekiAttia, Ramy NaguibArnold, Leggy A.Teske, KellyConnelly, MicheleLemieux, GeorgeAshrafi, KavehShelat, AnangGuy, R. Kiplin
- [36] The discovery of orally available thrombin inhibitors: Optimisation of the P1 pharmacophoreBIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1999, 9 (08) : 1103 - 1108Ambler, JBentley, DBrown, LDunnet, KFarr, DJanus, DLe Grand, DMenear, KMercer, MTalbot, MTweed, MWathey, B
- [37] Discovery of Potent, Orally Bioavailable Inhibitors of Human CytomegalovirusACS MEDICINAL CHEMISTRY LETTERS, 2016, 7 (05): : 525 - 530Fader, LeeBrault, MartineDesjardins, JessicaDansereau, NathalieLamorte, LouieTremblay, SoniaBilodeau, FrancoisBordeleau, JoseeDuplessis, MartinGorys, VidaGillard, JamesGleason, James L.James, ClintJoly, Marc-AndreKuhn, CyrilleLlinas-Brunet, MontseLuo, LaibinMorency, LouisMorin, SebastienParisien, MathieuPoirier, MaudeThibeault, CarlThao TrinhSturino, ClaudioSrivastava, SanjayYoakim, ChristianeFranti, Michael
- [38] Discovery of potent and orally bioavailable macrocyclic FXIa inhibitorsABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2017, 254Yang, Wu
- [39] Discovery and characterization of a high orally available small molecule inhibitor of KRASG12DEUROPEAN JOURNAL OF CANCER, 2024, 211 : S17 - S17Zhang, Y.Feng, Z.Huang, X.Sun, M.Yang, F.Yu, H.Chen, Z.Ying, H.
- [40] Discovery of bioactive small molecule inhibitors of human PD1-PDL1 interactionANNALS OF ONCOLOGY, 2019, 30Patil, S. P.Diflumeri, J.Fattakhova, E.