In vivo Volumetric, DTI and 1H MRS Rat Brain Protocol for Monitoring Early Neurodegeneration and Efficacy of the Used Therapy

被引：0

作者：

Tvrdik, Tomas ^{[1
,2
,3
]}

Melichercik, Lubomir ^{[1
,2
,3
]}

Sebekova, Katarina ^{[4
]}

Szabo, Jakub ^{[4
]}

Makova, Marianna ^{[1
]}

Gogola, Daniel ^{[5
]}

Kasparova, Svatava ^{[1
]}

机构：

[1] Slovak Univ Technol Bratislava, Fac Chem & Food Technol, Cent Labs, Radlinskeho 9, Bratislava 81237, Slovakia

[2] Slovak Med Univ, Comenius Univ Bratislava, Fac Med, Dept Radiol, Mickiewiczova 13, Bratislava 81369, Slovakia

[3] Univ Hosp Bratislava, Mickiewiczova 13, Bratislava 81369, Slovakia

[4] Comenius Univ, Fac Med, Inst Mol Biomed, Sasinkova 4, Bratislava 81108, Slovakia

[5] Slovak Acad Sci, Inst Measurement Sci, Dubravska Cesta 9, Bratislava 84104, Slovakia

来源：

MEASUREMENT SCIENCE REVIEW | 2023年 / 23卷 / 05期

关键词：

Animals; multimodal imaging; in vivo; diffusion tensor imaging (DTI); magnetic resonance spectroscopy (MRS); MAGNETIC-RESONANCE-SPECTROSCOPY; MILD COGNITIVE IMPAIRMENT; DIFFUSION TENSOR; ALZHEIMERS-DISEASE; WHITE-MATTER; ADVANCED GLYCATION; DEMENTIA; MEMORY; PREVALENCE; DIAGNOSIS;

D O I：

10.2478/msr-2023-0030

中图分类号：

TH7 [仪器、仪表];

学科分类号：

0804 ; 080401 ; 081102 ;

摘要：

The aim of our study was to develop a multimodal experimental protocol for in vivo imaging and metabolic parameters (MRI, DTI and H-1 MRS) in an animal model of neurodegeneration. We have successfully developed the protocol for simultaneous DTI/MRI/H-1 MRS measurement to ensure unaltered conditions for repeatable non-invasive experiments. In this experiment, diffusion tensor imaging, spectroscopic and volumetric "bio-markers" were generated in the brain for the D-galactose model of "age-related dementia". The hippocampal relative volume, taurine and myo-inositol relative concentrations were found to be significant predictors contributing to the differences between the groups of rats treated with D-galactose in simulated "neurodegeneration", even in response to the applied Huperzine A therapy.

引用

页码：237 / 247

页数：11

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