In vivo Volumetric, DTI and 1H MRS Rat Brain Protocol for Monitoring Early Neurodegeneration and Efficacy of the Used Therapy

被引：0
|
作者：
Tvrdik, Tomas [1 ,2 ,3 ]
Melichercik, Lubomir [1 ,2 ,3 ]
Sebekova, Katarina [4 ]
Szabo, Jakub [4 ]
Makova, Marianna [1 ]
Gogola, Daniel [5 ]
Kasparova, Svatava [1 ]
机构：
[1] Slovak Univ Technol Bratislava, Fac Chem & Food Technol, Cent Labs, Radlinskeho 9, Bratislava 81237, Slovakia
[2] Slovak Med Univ, Comenius Univ Bratislava, Fac Med, Dept Radiol, Mickiewiczova 13, Bratislava 81369, Slovakia
[3] Univ Hosp Bratislava, Mickiewiczova 13, Bratislava 81369, Slovakia
[4] Comenius Univ, Fac Med, Inst Mol Biomed, Sasinkova 4, Bratislava 81108, Slovakia
[5] Slovak Acad Sci, Inst Measurement Sci, Dubravska Cesta 9, Bratislava 84104, Slovakia
来源：
MEASUREMENT SCIENCE REVIEW | 2023年 / 23卷 / 05期
关键词：
Animals; multimodal imaging; in vivo; diffusion tensor imaging (DTI); magnetic resonance spectroscopy (MRS); MAGNETIC-RESONANCE-SPECTROSCOPY; MILD COGNITIVE IMPAIRMENT; DIFFUSION TENSOR; ALZHEIMERS-DISEASE; WHITE-MATTER; ADVANCED GLYCATION; DEMENTIA; MEMORY; PREVALENCE; DIAGNOSIS;
D O I：
10.2478/msr-2023-0030
中图分类号：
TH7 [仪器、仪表];
学科分类号：
0804 ; 080401 ; 081102 ;
摘要：
The aim of our study was to develop a multimodal experimental protocol for in vivo imaging and metabolic parameters (MRI, DTI and H-1 MRS) in an animal model of neurodegeneration. We have successfully developed the protocol for simultaneous DTI/MRI/H-1 MRS measurement to ensure unaltered conditions for repeatable non-invasive experiments. In this experiment, diffusion tensor imaging, spectroscopic and volumetric "bio-markers" were generated in the brain for the D-galactose model of "age-related dementia". The hippocampal relative volume, taurine and myo-inositol relative concentrations were found to be significant predictors contributing to the differences between the groups of rats treated with D-galactose in simulated "neurodegeneration", even in response to the applied Huperzine A therapy.
引用
收藏
页码：237 / 247
页数：11
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