Nitroreductase-sensitive fluorescent covalent organic framework for tumor hypoxia imaging in cells

被引：6

作者：

Skorjanc, Tina ^{[1
]}

Shetty, Dinesh ^{[2
,3
]}

Kumar, Sushil ^{[2
]}

Makuc, Damjan ^{[4
]}

Mali, Gregor ^{[4
]}

Volavsek, Janez ^{[4
]}

Bergant Marusic, Martina ^{[5
]}

Valant, Matjaz ^{[1
]}

机构：

[1] Univ Nova Gorica, Mat Res Lab, Vipavska 11c, Ajdovscina 5270, Slovenia

[2] Khalifa Univ, Dept Chem, POB 127788, Abu Dhabi, U Arab Emirates

[3] Khalifa Univ, Adv Mat Chem Ctr AMCC, POB 127788, Abu Dhabi, U Arab Emirates

[4] Natl Inst Chem, Slovenian NMR Ctr, Hajdrihova 19, Ljubljana 1000, Slovenia

[5] Univ Nova Gorica, Lab Environm & Life Sci, Vipavska 13, Nova Gorica 5000, Slovenia

来源：

CHEMICAL COMMUNICATIONS | 2023年 / 59卷 / 38期

关键词：

NANOSHEETS; OXYGEN; PROBE;

D O I：

10.1039/d3cc01110k

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Covalent organic frameworks (COFs) have been used in cell imaging, but very rarely for imaging specific cell conditions. Herein, a beta-ketoenamine-based fluorescent COF was post-synthetically modified to incorporate a hypoxia-targeting molecule. Fluorescence microscopy imaging shows that the material discriminates between HeLa cells grown under hypoxia and those cultured under normoxia.

引用

页码：5753 / 5756

页数：4

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