A dual-function fluorescent probe for monitoring the degrees of hypoxia in living cells via the imaging of nitroreductase and adenosine triphosphate

被引：114
|
作者：
Fang, Yu [1 ,2 ]
Shi, Wen [1 ]
Hu, Yiming [1 ]
Li, Xiaohua [1 ]
Ma, Huimin [1 ,2 ]
机构：
[1] Chinese Acad Sci, Inst Chem, Key Lab Analyt Chem Living Biosyst, Beijing 100190, Peoples R China
[2] Univ Chinese Acad Sci, Beijing 100049, Peoples R China
来源：
CHEMICAL COMMUNICATIONS | 2018年 / 54卷 / 43期
关键词：
LIVE CELLS; HYDROGEN POLYSULFIDES; ON PROBE; IN-VIVO; ATP; RECOGNITION; PROTECTION; BINDING; TUMORS; SITE;
D O I：
10.1039/c8cc02209g
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A new dual-function fluorescent probe is developed for detecting nitroreductase (NTR) and adenosine triphosphate (ATP) with different responses. Imaging application of the probe reveals that intracellular NTR and ATP display an adverse changing trend during a hypoxic process and ATP can serve as a new sign for cell hypoxia.
引用
收藏
页码：5454 / 5457
页数：4
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