Sesquiterpene Lactones with Anti-Inflammatory Activity from the Halophyte Sonchus brachyotus DC

被引：3
|
作者：
Lee, Young-Kyung [1 ]
Lee, Hangy [1 ]
Kim, Yun Na [2 ]
Kang, Jun [3 ]
Jeong, Eun Ju [2 ]
Rho, Jung-Rae [1 ]
机构：
[1] Kunsan Natl Univ, Dept Oceanog, Jeonbuk 54150, South Korea
[2] Gyeongsang Natl Univ, Dept Plant & Biomat Sci, Jinju 52725, South Korea
[3] Kunsan Natl Univ, Dept Marine Biotechnol, Jeonbuk 54150, South Korea
来源：
MOLECULES | 2023年 / 28卷 / 04期
关键词：
Sonchus brachyotus; eudesmanolide; sesquiterpene lactone; anti-inflammation;
D O I：
10.3390/molecules28041518
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
There were five sesquiterpene lactones, belonging to the eudesmanolide class, isolated from the halophyte Sonchus brachyotus DC. The structures of the compounds were determined using spectroscopic methods, including 1D and 2D NMR spectra, MS data, and optical rotation values. Compounds 4 and 5 were characterized by the position of p-hydroxyphenylacetyl group in the sugar moiety. In the evaluation of anti-inflammatory effects on LPS-activated RAW264.7 macrophages, compound 1, 5 alpha,6 beta H-eudesma-3,11(13)-dien-12,6 alpha-olide, potently suppressed the expression of iNOS and COS-2, as well as the production of TNF-alpha, IL-6, and IL-10. Treatment of 1 regulates the Nrf2/HO-1 pathway.
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页数：11
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