Sesquiterpene Lactones with Anti-Inflammatory Activity from the Halophyte Sonchus brachyotus DC

被引：3
|
作者：
Lee, Young-Kyung [1 ]
Lee, Hangy [1 ]
Kim, Yun Na [2 ]
Kang, Jun [3 ]
Jeong, Eun Ju [2 ]
Rho, Jung-Rae [1 ]
机构：
[1] Kunsan Natl Univ, Dept Oceanog, Jeonbuk 54150, South Korea
[2] Gyeongsang Natl Univ, Dept Plant & Biomat Sci, Jinju 52725, South Korea
[3] Kunsan Natl Univ, Dept Marine Biotechnol, Jeonbuk 54150, South Korea
来源：
MOLECULES | 2023年 / 28卷 / 04期
关键词：
Sonchus brachyotus; eudesmanolide; sesquiterpene lactone; anti-inflammation;
D O I：
10.3390/molecules28041518
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
There were five sesquiterpene lactones, belonging to the eudesmanolide class, isolated from the halophyte Sonchus brachyotus DC. The structures of the compounds were determined using spectroscopic methods, including 1D and 2D NMR spectra, MS data, and optical rotation values. Compounds 4 and 5 were characterized by the position of p-hydroxyphenylacetyl group in the sugar moiety. In the evaluation of anti-inflammatory effects on LPS-activated RAW264.7 macrophages, compound 1, 5 alpha,6 beta H-eudesma-3,11(13)-dien-12,6 alpha-olide, potently suppressed the expression of iNOS and COS-2, as well as the production of TNF-alpha, IL-6, and IL-10. Treatment of 1 regulates the Nrf2/HO-1 pathway.
引用
收藏
页数：11
相关论文
共 50 条
  • [31] Cajamolides A-N: Cytotoxic and anti-inflammatory sesquiterpene lactones from Calea jamaicensis
    Grafakou, Maria-Eleni
    Barda, Christina
    Karikas, George A.
    Heilmann, Joerg
    Skaltsa, Helen
    BIOORGANIC CHEMISTRY, 2021, 116
  • [32] Anti-inflammatory and anti-hyperalgesic effects of sesquiterpene lactones from Magnolia and Bear's foot
    Feltenstein, MW
    Schühly, W
    Warnick, JE
    Fischer, NH
    Sufka, KJ
    PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 2004, 79 (02) : 299 - 302
  • [33] Sesquiterpene lactones from Inula falconeri, a plant endemic to the Himalayas, as potential anti-inflammatory agents
    Cheng, Xiangrong
    Zeng, Qi
    Ren, Jie
    Qin, Jiangjiang
    Zhang, Shoude
    Shen, Yunheng
    Zhu, Jiaxian
    Zhang, Fei
    Chang, Ruijie
    Zhu, Yan
    Zhang, Weidong
    Jin, Huizi
    EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2011, 46 (11) : 5408 - 5415
  • [34] Anti-inflammatory sesquiterpene lactones from Tithonia diversifolia trigger different effects on human neutrophils
    Aneli E. Abe
    Carine E. de Oliveira
    Thalita M. Dalboni
    Daniela A. Chagas-Paula
    Bruno A. Rocha
    Rejane B. de Oliveira
    Thais H. Gasparoto
    Fernando B. Da Costa
    Ana P. Campanelli
    Revista Brasileira de Farmacognosia, 2015, 25 : 111 - 116
  • [35] Anti-inflammatory sesquiterpene lactones from Tithonia diversifolia trigger different effects on human neutrophils
    Abe, Aneli E.
    de Oliveira, Carine E.
    Dalboni, Thalita M.
    Chagas-Paula, Daniela A.
    Rocha, Bruno A.
    de Oliveira, Rejane B.
    Gasparoto, Thais H.
    da Costa, Fernando B.
    Campanelli, Ana P.
    REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY, 2015, 25 (02): : 111 - 116
  • [36] Isolation and anti-inflammatory activity of the sesquiterpene lactone dihydrolactucopicrin
    Schmidt, Barbara M.
    Dey, Moul
    Poulev, Alexander
    Ilic, Nebojsa
    Raskin, Ilya
    FASEB JOURNAL, 2007, 21 (05): : A733 - A733
  • [37] Further sesquiterpene lactones from viguiera robusta and the potential anti-inflammatory activity of a heliangolide:: Inhibition of human neutrophil elastase release
    Arakawa, Nilton S.
    Schorr, Karin
    Ambrosio, Sergio R.
    Merfort, Irmgard
    Da Costa, Fernando B.
    ZEITSCHRIFT FUR NATURFORSCHUNG SECTION C-A JOURNAL OF BIOSCIENCES, 2008, 63 (7-8): : 533 - 538
  • [38] Anti-inflammatory sesquiterpene lactones from Onopordum illyricum L. (Asteraceae), an Italian medicinal plant
    Formisano, Carmen
    Sanna, Cinzia
    Ballero, Mauro
    Chianese, Giuseppina
    Sirignano, Carmina
    Rigano, Daniela
    Millan, Estrella
    Munoz, Eduardo
    Taglialatela-Scafati, Orazio
    FITOTERAPIA, 2017, 116 : 61 - 65
  • [39] Sesquiterpene lactones from Lychnophora species: Antinociceptive, anti-inflammatory, and antioxidant pathways to treat acute gout
    Fernandes Pereira Ferreira Bernardes, Ana Catharina
    Matosinhos, Rafaela Cunha
    de Paula Michel Araujo, Marcela Carolina
    Barros, Camila Helena
    de Oliveira Aguiar Soares, Rodrigo Dian
    Costa, Daniela Caldeira
    Sachs, Daniela
    Saude-Guimaraes, Denia Antunes
    JOURNAL OF ETHNOPHARMACOLOGY, 2021, 269
  • [40] Sesquiterpene lactones from Sonchus palustris L. (Asteraceae, Cichorieae)
    Shulha, Oleksandr
    Cicek, Serhat Sezai
    Piccolella, Simona
    Rarova, Lucie
    Strnad, Miroslav
    Soennichsen, Frank
    Pacifico, Severina
    Zidorn, Christian
    PHYTOCHEMISTRY, 2020, 170
12345