Establishment of cancer cell line originating from a patient with high-grade serous ovarian carcinoma

被引：1

作者：

Linh, Nguyen Thuy ^{[1
,2
,3
]}

Hang, Ngo Thu ^{[1
]}

Cuong, Bui Khac ^{[1
,4
]}

Linh, Dang Thuy ^{[1
]}

Linh, Nham Thi Phuong ^{[4
]}

Nguyen-Van, Do ^{[5
]}

Dzung, Tran Ngoc ^{[2
]}

Mao, Can Van ^{[1
]}

Chung, Dang Thanh ^{[2
]}

Chinh, Le Tri ^{[6
]}

Hung, Nguyen Phu ^{[7
]}

Tong, Hoang Van ^{[1
,8
]}

Toan, Nguyen Linh ^{[1
]}

机构：

[1] Vietnam Mil Med Univ, Dept Pathophysiol, Hanoi, Vietnam

[2] Vietnam Mil Med Univ, Mil Hosp 103, Dept Pathol, Hanoi, Vietnam

[3] Hanoi Med Univ, Dept Pathol, Hanoi, Vietnam

[4] Vietnam Mil Med Univ, Lab Anim Res Ctr, Hanoi, Vietnam

[5] Hanoi Med Univ, Dept Pathophysiol & Immunol, Hanoi, Vietnam

[6] Vietnam Natl Canc Hosp, Dept Gynaecol Surg, Hanoi, Vietnam

[7] Thai Nguyen Univ Sci, Fac Biotechnol, Thai Nguyen, Vietnam

[8] Vietnam Mil Med Univ, Inst Biomed & Pharm, Hanoi, Vietnam

来源：

FUTURE SCIENCE OA | 2023年 / 9卷 / 08期

关键词：

CD46; cell line; high-grade serous carcinoma; immunohistochemistry; ovarian cancer;

D O I：

10.2144/fsoa-2023-0025

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Aim: Ovarian cancer is a serious malignancy with high prevalence and mortality. Methods: We isolated and characterized an ovarian high-grade serous cancer cell line (M4) from a tumor of a Vietnamese patient with ovarian carcinoma. Results: The M4 cancer cell line showed good proliferation and stability in culture. Morphologically, the M4 cells showed similar characteristics to tumor cells such as a polyhedral shape, large irregular nuclei, high nuclear/cytoplasmic ratio, high nuclear density and expressing cancer markers like CA125, p53 and Ki67 markers. Conclusion: We have successfully isolated and characterized the M4 cell line from a Vietnamese patient with ovarian carcinoma.

引用

页数：13

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