Establishment of cancer cell line originating from a patient with high-grade serous ovarian carcinoma

被引：1
|
作者：
Linh, Nguyen Thuy [1 ,2 ,3 ]
Hang, Ngo Thu [1 ]
Cuong, Bui Khac [1 ,4 ]
Linh, Dang Thuy [1 ]
Linh, Nham Thi Phuong [4 ]
Nguyen-Van, Do [5 ]
Dzung, Tran Ngoc [2 ]
Mao, Can Van [1 ]
Chung, Dang Thanh [2 ]
Chinh, Le Tri [6 ]
Hung, Nguyen Phu [7 ]
Tong, Hoang Van [1 ,8 ]
Toan, Nguyen Linh [1 ]
机构：
[1] Vietnam Mil Med Univ, Dept Pathophysiol, Hanoi, Vietnam
[2] Vietnam Mil Med Univ, Mil Hosp 103, Dept Pathol, Hanoi, Vietnam
[3] Hanoi Med Univ, Dept Pathol, Hanoi, Vietnam
[4] Vietnam Mil Med Univ, Lab Anim Res Ctr, Hanoi, Vietnam
[5] Hanoi Med Univ, Dept Pathophysiol & Immunol, Hanoi, Vietnam
[6] Vietnam Natl Canc Hosp, Dept Gynaecol Surg, Hanoi, Vietnam
[7] Thai Nguyen Univ Sci, Fac Biotechnol, Thai Nguyen, Vietnam
[8] Vietnam Mil Med Univ, Inst Biomed & Pharm, Hanoi, Vietnam
来源：
FUTURE SCIENCE OA | 2023年 / 9卷 / 08期
关键词：
CD46; cell line; high-grade serous carcinoma; immunohistochemistry; ovarian cancer;
D O I：
10.2144/fsoa-2023-0025
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Aim: Ovarian cancer is a serious malignancy with high prevalence and mortality. Methods: We isolated and characterized an ovarian high-grade serous cancer cell line (M4) from a tumor of a Vietnamese patient with ovarian carcinoma. Results: The M4 cancer cell line showed good proliferation and stability in culture. Morphologically, the M4 cells showed similar characteristics to tumor cells such as a polyhedral shape, large irregular nuclei, high nuclear/cytoplasmic ratio, high nuclear density and expressing cancer markers like CA125, p53 and Ki67 markers. Conclusion: We have successfully isolated and characterized the M4 cell line from a Vietnamese patient with ovarian carcinoma.
引用
收藏
页数：13
相关论文
共 50 条
  • [31] Proteogenomic characterization of high-grade serous ovarian cancer
    McDermott, Jason E.
    Payne, Samuel
    Ray, Debjit
    Petyuk, Vladislav
    Moore, Ronald
    Gritsenko, Marina
    Smith, Richard
    Rodland, Karin
    CANCER RESEARCH, 2016, 76
  • [32] High-grade serous ovarian cancer: the clone wars
    Aleksander Salomon-Perzyński
    Magdalena Salomon-Perzyńska
    Bogdan Michalski
    Violetta Skrzypulec-Plinta
    Archives of Gynecology and Obstetrics, 2017, 295 : 569 - 576
  • [33] High-grade serous ovarian cancer: the clone wars
    Salomon-Perzynski, Aleksander
    Salomon-Perzynska, Magdalena
    Michalski, Bogdan
    Skrzypulec-Plinta, Violetta
    ARCHIVES OF GYNECOLOGY AND OBSTETRICS, 2017, 295 (03) : 569 - 576
  • [34] The role of Apela in high-grade serous ovarian cancer
    Daily, Laura R.
    Ganguly, Debolina
    Hayes, D. Neil
    Wang, Yinan
    Sims, Michelle M.
    Cheng, Jinjun
    ElNaggar, Adam C.
    Pfeffer, Lawrence M.
    CANCER RESEARCH, 2018, 78 (13)
  • [35] Drugs Repurposing in High-Grade Serous Ovarian Cancer
    Torralba, Manuel
    Farra, Rossella
    Maddaloni, Marianna
    Grassi, Mario
    Dapas, Barbara
    Grassi, Gabriele
    CURRENT MEDICINAL CHEMISTRY, 2020, 27 (42) : 7222 - 7233
  • [36] High-grade serous ovarian carcinoma in a patient with end-stage renal disease
    Gajic, Selena
    Dzamic, Vanja
    Bontic, Ana
    Petrovic, Kristina
    Kezic, Aleksandra
    VOJNOSANITETSKI PREGLED, 2024, 81 (05) : 326 - 330
  • [37] Histologic and molecular analysis of patient derived xenografts of high-grade serous ovarian carcinoma
    Ruifen Dong
    Wenan Qiang
    Haiyang Guo
    Xiaofei Xu
    J. Julie Kim
    Andrew Mazar
    Beihua Kong
    Jian-Jun Wei
    Journal of Hematology & Oncology, 9
  • [38] Early Genetic Divergence of High-Grade Carcinomas Originating from Low-Grade Serous Ovarian Neoplasms
    Chui, M. Herman
    Song, Qianqian
    Zhu, Jiarun
    Jiao, Yuchen
    Wang, Brant
    Wang, Yeh
    Wang, Tian-Li
    Vang, Russell
    Shih, Ie-Ming
    MODERN PATHOLOGY, 2025, 38 (01)
  • [39] Establishment and analysis of patient-derived high-grade serous ovarian cancer organoids for disease modeling and drug testing
    Kallunki, Tuula
    Lauridsen, Anna R.
    Skorda, Aikaterini
    Lahtinen, Alexandra
    Bay, Marie L.
    Rasmussen, Benita
    Huhtinen, Kaisa
    Muranen, Taru
    Oikkonen, Jaana
    Hynninen, Johanna
    Hautaniemi, Sampsa
    CANCER RESEARCH, 2024, 84 (06)
  • [40] HMGA2 and high-grade serous ovarian carcinoma
    Jingjing Wu
    Jian-Jun Wei
    Journal of Molecular Medicine, 2013, 91 : 1155 - 1165
12345