Aminomethylation of Uracil and 6-Methyluracil by 3,4-dimethoxyphenylethylamine and Tetrahydroisoquinoline Derivatives

被引：0

作者：

Zhurakulov, Sh. N. ^{[1
,2
]}

Rakhimov, Sh. B. ^{[1
]}

Kodirov, M. A. ^{[1
]}

Vinogradova, V. I. ^{[1
]}

Sagdullaev, Sh. Sh. ^{[1
]}

机构：

[1] Acad Sci Uzbek, S Yu Yunusov Inst Chem Plant Subst, Tashkent 100170, Uzbekistan

[2] Natl Univ Uzbekistan, Tashkent 100174, Uzbekistan

来源：

CHEMISTRY OF NATURAL COMPOUNDS | 2023年 / 59卷 / 02期

关键词：

uracil; 6-methyluracil; 3; 4-dimethoxyphenylethylamine; 1-aryltetrahydroisoquinolines; formalin; Mannich reaction;

D O I：

10.1007/s10600-023-03987-9

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The Mannich reactions of uracil and 6-methyluracil with homoveratrylamine and 1-aryltetrahydroisoquinolines in EtOH and dioxane were studied. 5-[(2-Hydroxymethyl)-4,5-dimethoxyphenylethylamino)methyl]-6-methylpyrimidine-2,4(1H, 3H)-dione was formed in EtOH in addition to the usual products (in dioxane).

引用

页码：331 / 335

页数：5

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