Aminomethylation of Uracil and 6-Methyluracil by 3,4-dimethoxyphenylethylamine and Tetrahydroisoquinoline Derivatives

被引：0
|
作者：
Zhurakulov, Sh. N. [1 ,2 ]
Rakhimov, Sh. B. [1 ]
Kodirov, M. A. [1 ]
Vinogradova, V. I. [1 ]
Sagdullaev, Sh. Sh. [1 ]
机构：
[1] Acad Sci Uzbek, S Yu Yunusov Inst Chem Plant Subst, Tashkent 100170, Uzbekistan
[2] Natl Univ Uzbekistan, Tashkent 100174, Uzbekistan
来源：
CHEMISTRY OF NATURAL COMPOUNDS | 2023年 / 59卷 / 02期
关键词：
uracil; 6-methyluracil; 3; 4-dimethoxyphenylethylamine; 1-aryltetrahydroisoquinolines; formalin; Mannich reaction;
D O I：
10.1007/s10600-023-03987-9
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The Mannich reactions of uracil and 6-methyluracil with homoveratrylamine and 1-aryltetrahydroisoquinolines in EtOH and dioxane were studied. 5-[(2-Hydroxymethyl)-4,5-dimethoxyphenylethylamino)methyl]-6-methylpyrimidine-2,4(1H, 3H)-dione was formed in EtOH in addition to the usual products (in dioxane).
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页码：331 / 335
页数：5
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