The role of hyperleptinaemia and low values of interleukin 10 in de novo DSA production after kidney transplantation

被引:0
|
作者
Dedinska, Ivana [1 ,2 ,3 ,5 ]
Kleinova, Patricia [1 ,2 ,3 ]
Machalekova, Katarina [4 ]
Granak, Karol [1 ,2 ,3 ]
Vnucak, Matej [1 ,2 ,3 ]
Beliancinova, Monika [1 ,2 ,3 ]
机构
[1] Univ Hosp Martin, Transplant Ctr, Martin, Slovakia
[2] Comenius Univ, Jessenius Fac Med, Bratislava, Slovakia
[3] Univ Hosp Martin, Dept Internal Dis 1, Martin, Slovakia
[4] St Elizabeth Canc Inst, Dept Pathol, Bratislava, Slovakia
[5] Univ Hosp Martin, Transplant Ctr, Kollarova 2, Martin 03601, Slovakia
关键词
Leptin; IL-10; Protocol biopsy; Kidney transplantation; LEPTIN LEVELS; BODY-FAT; POLYMORPHISMS; ADIPONECTIN; ACTIVATION; DISEASE; WEIGHT; IL-10; ALPHA; INDEX;
D O I
10.1016/j.trim.2023.101982
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Background: White adipose tissue secretes a number of peptide hormones. The aim of this paper was to determine the role of leptin, adiponectin and interleukin-10 and interleukin-6 on the development of graft rejection in protocol biopsy after kidney transplantation. Methods: In a prospective analysis (n = 104), we monitored the values of leptin, adiponectin, IL -6, and IL -10 prior to the transplantation and in the 3rd month after the transplantation. The protocol biopsy of the graft was performed in the 3rd month after the transplantation. The group was divided into the following according to the biopsy result: negative result, IFTA 1, borderline, and DSA positive. Results: After adjusting for the differences in the baseline recipient and donor characteristics, we identified the hyperleptinaemia baseline (HR = 2.0444, P = 0.0341) and month 3 (HR = 49.8043, P < 0.0001) as independent risk factors for borderline changes in the protocol biopsy. The hyperleptinaemia baseline (HR = 7.4979, P = 0.0071) and month 3 (HR = 9.7432, P = 0.0057) are independent risk factors for de novo DSA positivity. A low value of IL -10 month 3 is a risk factor for de novo DSA positivity (HR = 3.0746, P = 0.0388). Conclusions: Higher leptin levels and low values of IL -10 might play a role in rejection and de novo DSA production.
引用
收藏
页数:6
相关论文
共 50 条
  • [31] De Novo Production of IgG3+DSA Is Associated with Poor Graft Survival after Heart Transplantation
    Nguyen, A.
    Smith, J. D.
    Everly, M. J.
    Hamour, I. M.
    Banner, N. R.
    Rose, M. L.
    Terasaki, P. I.
    AMERICAN JOURNAL OF TRANSPLANTATION, 2012, 12 : 122 - 122
  • [32] A 13 YEAR STUDY TO INVESTIGATE PRODUCTION OF DE NOVO DSA ON GRAFT SURVIVAL AFTER HEART TRANSPLANTATION.
    Anh Nguyen
    Smith, John D.
    Everly, Matthew J.
    Banner, Nicholas R.
    Hamour, Iman M.
    Rose, Marlene L.
    Terasaki, Paul I.
    HUMAN IMMUNOLOGY, 2011, 72 : S188 - S188
  • [33] Negative Impact of De Novo Donor-Specific Anti-HLA Antibodies (De Novo DSA) after Living Donor Kidney Transplantation.
    Omoto, Kazuya
    Ishida, Hideki
    Shimizu, Tomokazu
    Shirakawa, Hiroki
    Toki, Daisuke
    Iida, Shouichi
    Tokita, Daisuke
    Furusawa, Miyuki
    Tanabe, Kazunari
    AMERICAN JOURNAL OF TRANSPLANTATION, 2009, 9 : 585 - 585
  • [34] Protocol Biopsies in Patients With Subclinical De Novo DSA After Kidney Transplantation: Long-term Graft Survival
    Bertrand, Dominique
    Gatault, Philippe
    Jaureguy, Maite
    Garrouste, Cyril
    Duveau, Agnes
    Bouvier, Nicolas
    Caillard, Sophie
    Lanfranco, Luca
    Thierry, Antoine
    Laurent, Charlotte
    Farce, Fabienne
    Francois, Arnaud
    Guerrot, Dominique
    TRANSPLANTATION, 2024, 108 (08) : E204 - E206
  • [35] De novo tumors after kidney transplantation:: The Budapest experience
    Langer, RM
    Járay, J
    Tóth, A
    Hídvégi, M
    Végsö, G
    Perner, F
    TRANSPLANTATION PROCEEDINGS, 2003, 35 (04) : 1396 - 1398
  • [36] Diagnosis of de novo thrombotic microangiopathy after kidney transplantation
    Braet, Pauline
    Sprangers, Ben
    Dierickx, Daan
    ACTA CLINICA BELGICA, 2016, 71 : 31 - 31
  • [37] Recurent and De Novo Membranous Glomerulopathy After Kidney Transplantation
    Aline-Fardin, A.
    Rifle, G.
    Martin, L.
    Justrabo, E.
    Bour, J. B.
    D'Athis, P.
    Tanter, Y.
    Mousson, C.
    TRANSPLANTATION PROCEEDINGS, 2009, 41 (02) : 669 - 671
  • [38] De novo minimal change disease after kidney transplantation
    Alirezaei, Amirhesam
    Zare, Elham
    Parvin, Mahmoud
    Nili, Fatemeh
    Bakhtiyari, Mahmood
    JOURNAL OF RENAL INJURY PREVENTION, 2018, 7 (02): : 103 - 106
  • [39] Trough Level of Mycophenolic Acid Did Not Affect De Novo DSA Development in Kidney Transplantation
    Masaki, Noriyuki
    Iwadoh, Kazuhiro
    Tonsho, Makoto
    Koyama, Ichiro
    Nakajima, Ichiro
    Fuchinoue, Shohei
    TRANSPLANTATION PROCEEDINGS, 2019, 51 (08) : 2624 - 2628
  • [40] THE ROLE OF PRIMARY DISEASE FOR THE DEVELOPMENT OF DE NOVO DONOR SPECIFIC ANTIBODIES AFTER KIDNEY TRANSPLANTATION
    Lionaki, Sophia
    Drouzas, Konstantinos
    Pappas, Apostolos
    Kapsia, Helen
    Altanis, Nikolaos
    Liapis, George
    Iniotaki, Alice
    Zavos, George
    Boletis, John
    TRANSPLANT INTERNATIONAL, 2015, 28 : 358 - 358