Regulation of litter size in sheep (Ovis aries) by the GDF9 and BMP15 genes

被引：3

作者：

Chen, Yang ^{[1
]}

Shan, Xuesong ^{[1
]}

Jiang, Huaizhi ^{[1
]}

Sun, Limin ^{[1
]}

Guo, Zhenhua ^{[2
]}

机构：

[1] Jilin Agr Univ, Coll Anim Sci & Technol, Key Lab Livestock & Poultry Resources Sheep & Goat, Minist Agr & Rural Affairs, Changchun 130118, Peoples R China

[2] Heilongjiang Acad Agr Sci, Anim Husb Res Inst, Harbin 150086, Peoples R China

来源：

ANNALS OF AGRICULTURAL SCIENCES | 2023年 / 68卷 / 02期

关键词：

Ewe; Follicle; Lambing size; Meta-analysis; Protein docking; MORPHOGENETIC PROTEIN 15; CHINESE INDIGENOUS SHEEP; OVULATION RATE; FECUNDITY GENES; BMPR-IB; GDF9; POLYMORPHISMS; MUTATIONS; PROLIFICACY; EXPRESSION;

D O I：

10.1016/j.aoas.2023.12.004

中图分类号：

S [农业科学];

学科分类号：

09 ;

摘要：

The mutation types GDF9 S395F and S427R increase the ovulation rate in heterozygotes, while the homozygous form leads to infertility. This study presents a meta-analysis of GDF9 and BMP15 SNPs related to sheep litter size (LS). The results showed that simulation of the molecular recognition of GDF9 R453H, S395F, and S427R was per-formed to study the effect on the GDF9 dimer. S395F and S427R dimer binding ability of mutant heterozygotes was improved, thereby improving LS. The binding ability of mutant homozygous dimers was reduced, resulting in infertility. The results of this study will provide important references for animal breeding.(c) 2023 Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

引用

页码：148 / 158

页数：11

共 50 条

[41] Association of BMP15 and GDF9 variants to premature ovarian insufficiency
Santos, Monise
Cordts, Emerson Barchi
Peluso, Carla
Dornas, Mayla
Neto, Felipe Heurre Vieira
Bianco, Bianca
Barbosa, Caio Parente
Christofolini, Denise Maria
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS, 2019, 36 (10) : 2163 - 2169
[42] Polymorphisms in GDF9 and BMP15 Associated with Fertility and Ovulation Rate in Moghani and Ghezel Sheep in Iran
Barzegari, A.
Atashpaz, S.
Ghabili, K.
Nemati, Z.
Rustaei, M.
Azarbaijani, R.
REPRODUCTION IN DOMESTIC ANIMALS, 2010, 45 (04) : 666 - 669
[43] Novel Single Nucleotide Polymorphisms (SNPs) in Two Oogenesis Specific Genes (BMP15, GDF9) and Their Association with Litter Size in Markhoz Goat (Iranian Angora)
Arefnejad, B.
Mehdizadeh, Y.
Javanmard, A.
Zamiri, M. J.
Niazi, A.
IRANIAN JOURNAL OF APPLIED ANIMAL SCIENCE, 2018, 8 (01): : 91 - 99
[44] The proregion of mBMP15 regulates the cooperative interactions of BMP15 and GDF9
McIntosh, Joy
Lun, Stan
Lawrence, Steve
McNatty, Kenneth
Juengel, Jennifer
BIOLOGY OF REPRODUCTION, 2008, : 129 - 130
[45] Molecular forms of ruminant BMP15 and GDF9 and putative interactions with receptors
Heath, Derek A.
Pitman, Janet L.
McNatty, Kenneth P.
REPRODUCTION, 2017, 154 (04) : 521 - 534
[46] Immunolocalization of GDF9 and BMP15 during in vitro maturation of canine oocytes
De los Reyes, M.
Palomino, J.
Martinez, V.
Rojas, C.
REPRODUCTION IN DOMESTIC ANIMALS, 2012, 47 : 535 - 535
[47] Molecular Aspects and Clinical Relevance of GDF9 and BMP15 in Ovarian Function
Belli, Martina
Shimasaki, Shunichi
OVARIAN CYCLE, 2018, 107 : 317 - 348
[48] Detection of Polymorphisms in BMP15 and GDF9 Genes and Their Associations with Reproductive Traits in Black Bengal Goat of Bangladesh
Mou, M. A.
Hridoy, M. F. A.
Desha, N. H.
Ahmed, S.
Bhuiyan, M. S. A.
TROPICAL ANIMAL SCIENCE JOURNAL, 2024, 47 (02) : 141 - 148
[49] PCR-RFLP-based identification of polymorphisms in BMPR1B, GDF9 and BMP15 genes associated with litter size in Beetal and Teddy goats
Islam, M.
Basheer, A.
Javed, K.
Anjum, A. A.
Zahoor, I
SOUTH AFRICAN JOURNAL OF ANIMAL SCIENCE, 2019, 49 (04) : 697 - 708
[50] Oocyte-Secreted Serum Biomarkers GDF9 and BMP15 in Women with Endometriosis
Aiat Shamsa
Robert B. Gilchrist
David M. Robertson
Rachael J. Rodgers
Mark W. Donoghoe
William L. Ledger
Jason A. Abbott
Angelique H. Riepsamen
Reproductive Sciences, 2023, 30 : 1521 - 1527

← 1 2 3 4 5 →