Regulation of litter size in sheep (Ovis aries) by the GDF9 and BMP15 genes

被引：3

作者：

Chen, Yang ^{[1
]}

Shan, Xuesong ^{[1
]}

Jiang, Huaizhi ^{[1
]}

Sun, Limin ^{[1
]}

Guo, Zhenhua ^{[2
]}

机构：

[1] Jilin Agr Univ, Coll Anim Sci & Technol, Key Lab Livestock & Poultry Resources Sheep & Goat, Minist Agr & Rural Affairs, Changchun 130118, Peoples R China

[2] Heilongjiang Acad Agr Sci, Anim Husb Res Inst, Harbin 150086, Peoples R China

来源：

ANNALS OF AGRICULTURAL SCIENCES | 2023年 / 68卷 / 02期

关键词：

Ewe; Follicle; Lambing size; Meta-analysis; Protein docking; MORPHOGENETIC PROTEIN 15; CHINESE INDIGENOUS SHEEP; OVULATION RATE; FECUNDITY GENES; BMPR-IB; GDF9; POLYMORPHISMS; MUTATIONS; PROLIFICACY; EXPRESSION;

D O I：

10.1016/j.aoas.2023.12.004

中图分类号：

S [农业科学];

学科分类号：

09 ;

摘要：

The mutation types GDF9 S395F and S427R increase the ovulation rate in heterozygotes, while the homozygous form leads to infertility. This study presents a meta-analysis of GDF9 and BMP15 SNPs related to sheep litter size (LS). The results showed that simulation of the molecular recognition of GDF9 R453H, S395F, and S427R was per-formed to study the effect on the GDF9 dimer. S395F and S427R dimer binding ability of mutant heterozygotes was improved, thereby improving LS. The binding ability of mutant homozygous dimers was reduced, resulting in infertility. The results of this study will provide important references for animal breeding.(c) 2023 Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

引用

页码：148 / 158

页数：11

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