Glutamine antagonist prodrug JHU083 reprograms immunosuppressive tumor-associated macrophages to drive tumor immunity in urologic cancers

被引：0
|
作者：
Praharaj, Monali
Shen, Fan
Lee, Alex J.
Zhao, Liang
Nirschl, Thomas R.
Wang, Xiaoxu
Theodros, Debebe
Singh, Alok K.
Williams, Raekwon A.
Sena, Laura A.
Thompson, Elizabeth A.
Tam, Ada
Yegnasubramanian, Srinivasan
Pearce, Edward J.
Leone, Robert D.
Alt, Jesse
Rais, Rana
Slusher, Barbara S.
Pardoll, Drew M.
Powell, Jonathan D.
Zarif, Jelani C.
机构：
来源：
CANCER RESEARCH | 2023年 / 83卷 / 11期
关键词：
D O I：
10.1158/1538-7445.PRCA2023-A079
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
A079
引用
收藏
页数：3
相关论文
共 50 条
  • [1] Glutamine antagonist prodrug JHU083 reprograms immunosuppressive tumor-associated macrophages (TAMs) to drive tumor immunity in urologic cancers
    Praharaj, Monali
    Shen, Fan
    Lee, Alex J.
    Zhao, Liang
    Nirschl, Thomas
    Wang, Xiaoxu
    Theodros, Debebe
    Singh, Alok K.
    Williams, Raekwon A.
    Sena, Laura A.
    Thompson, Elizabeth A.
    Tam, Ada
    Yegnasubramanian, Srinivasan
    Pearce, Edward J.
    Leone, Robert D.
    Alt, Jesse
    Rais, Rana
    Slusher, Barbara S.
    Pardoll, Andrew M.
    Powell, Jonathan D.
    Zarif, Jelani C.
    CANCER RESEARCH, 2023, 83 (07)
  • [2] GLUTAMINE ANTAGONIST PRODRUG JHU083 REPROGRAMS IMMUNOSUPPRESSIVE TUMOR-ASSOCIATED MACROPHAGES TO DRIVES TUMOR IMMUNITY IN UROLOGIC CANCERS
    Praharaj, Monali
    Shen, Fan
    Nirschl, Thomas
    Lee, Alee
    Wang, Xiaoxu
    Zhao, Liang
    Singh, Alok
    Theodros, Debebe
    Sena, Laura
    Thompson, Elizabeth
    Tam, Ada
    Yegnasubramanian, Srinivasan
    Pearce, Edward
    Leone, Robert
    Alt, Jesse
    Rais, Rana
    Slusher, Barbara
    Pardoll, Andrew
    Powell, Jonathan
    Zarif, Jelani
    JOURNAL FOR IMMUNOTHERAPY OF CANCER, 2022, 10 : A1163 - A1163
  • [3] Glutamine blockade via prodrug JHU083 reprograms immunosuppressive tumor associated macrophages (TAMs) and drives tumor immunity in urologic cancers
    Praharaj, Monali
    Shen, Fan
    Zhao, Liang
    Nirschl, Thomas R.
    Sena, Laura
    Singh, Alok K.
    Theodros, Debebe
    Wang, Xiaoxu
    Williams, Raekwon A.
    Thompson, Elizabeth
    Tam, Ada
    Yegnasubramanian, Srinivasan
    Leone, Robert D.
    Al, Jesse
    Rais, Rana
    Slusher, Barbara S.
    Pardoll, Drew M.
    Powell, Jonathan D.
    Zarif, Jelani C.
    CANCER RESEARCH, 2022, 82 (12)
  • [4] Metabolic Reprogramming of Tumor-Associated Macrophages Using Glutamine Antagonist JHU083 Drives Tumor Immunity in Myeloid-Rich Prostate and Bladder Cancers
    Praharaj, Monali
    Shen, Fan
    Lee, Alex J.
    Zhao, Liang
    Nirschl, Thomas R.
    Theodros, Debebe
    Singh, Alok K.
    Wang, Xiaoxu
    Adusei, Kenneth M.
    Lombardo, Kara A.
    Williams, Raekwon A.
    Sena, Laura A.
    Thompson, Elizabeth A.
    Tam, Ada
    Yegnasubramanian, Srinivasan
    Pearce, Edward J.
    Leone, Robert D.
    Alt, Jesse
    Rais, Rana
    Slusher, Barbara S.
    Pardoll, Drew M.
    Powell, Jonathan D.
    Zarif, Jelani C.
    CANCER IMMUNOLOGY RESEARCH, 2024, 12 (07) : 854 - 875
  • [5] Tumor-Associated Macrophages in Tumor Immunity
    Pan, Yueyun
    Yu, Yinda
    Wang, Xiaojian
    Zhang, Ting
    FRONTIERS IN IMMUNOLOGY, 2020, 11
  • [6] Tumor-associated macrophages in cancers
    Hu, W.
    Li, X.
    Zhang, C.
    Yang, Y.
    Jiang, J.
    Wu, C.
    CLINICAL & TRANSLATIONAL ONCOLOGY, 2016, 18 (03): : 251 - 258
  • [7] Tumor-associated macrophages in cancers
    W. Hu
    X. Li
    C. Zhang
    Y. Yang
    J. Jiang
    C. Wu
    Clinical and Translational Oncology, 2016, 18 : 251 - 258
  • [8] Tumor-Associated Macrophages as Major Immunosuppressive Cells in the Tumor Microenvironment
    Ghebremedhin, Anghesom
    Athavale, Dipti
    Zhang, Yanting
    Yao, Xiaodan
    Balch, Curt
    Song, Shumei
    CANCERS, 2024, 16 (19)
  • [9] Metabolism as checkpoint: Induction of anti-tumor immune response with the novel glutamine antagonist JHU-083
    Leone, Robert D.
    Englert, Judson M.
    Oh, Min-Hee
    Cheng, Chih-Hsien
    Rais, Rana
    Slusher, Barbara
    Powell, Jonathan D.
    CANCER RESEARCH, 2017, 77
  • [10] Glutamine Antagonist JHU083 Normalizes Aberrant Glutamate Production and Cognitive Deficits in the EcoHIV Murine Model of HIV-Associated Neurocognitive Disorders
    Michael T. Nedelcovych
    Boe-Hyun Kim
    Xiaolei Zhu
    Lyndah E. Lovell
    Arena A. Manning
    Jennifer Kelschenbach
    Eran Hadas
    Wei Chao
    Eva Prchalová
    Ranjeet P. Dash
    Ying Wu
    Jesse Alt
    Ajit G. Thomas
    Rana Rais
    Atsushi Kamiya
    David J. Volsky
    Barbara S. Slusher
    Journal of Neuroimmune Pharmacology, 2019, 14 : 391 - 400
12345