Glutamine antagonist prodrug JHU083 reprograms immunosuppressive tumor-associated macrophages to drive tumor immunity in urologic cancers

被引：0
|
作者：
Praharaj, Monali
Shen, Fan
Lee, Alex J.
Zhao, Liang
Nirschl, Thomas R.
Wang, Xiaoxu
Theodros, Debebe
Singh, Alok K.
Williams, Raekwon A.
Sena, Laura A.
Thompson, Elizabeth A.
Tam, Ada
Yegnasubramanian, Srinivasan
Pearce, Edward J.
Leone, Robert D.
Alt, Jesse
Rais, Rana
Slusher, Barbara S.
Pardoll, Drew M.
Powell, Jonathan D.
Zarif, Jelani C.
机构：
来源：
CANCER RESEARCH | 2023年 / 83卷 / 11期
关键词：
D O I：
10.1158/1538-7445.PRCA2023-A079
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
A079
引用
收藏
页数：3
相关论文
共 50 条
  • [31] Tumor cell-imposed iron restriction drives immunosuppressive polarization of tumor-associated macrophages
    Jia-Lei Sun
    Ning-Ping Zhang
    Ru-Chen Xu
    Guang-Cong Zhang
    Zhi-Yong Liu
    Weinire Abuduwaili
    Fu Wang
    Xiang-Nan Yu
    Xuan Shi
    Guang-Qi Song
    Hao Wu
    Tao-Tao Liu
    Xi-Zhong Shen
    Bin Deng
    Shu-Qiang Weng
    Ling Dong
    Ji-Min Zhu
    Journal of Translational Medicine, 19
  • [32] Tumor cell-imposed iron restriction drives immunosuppressive polarization of tumor-associated macrophages
    Sun, Jia-Lei
    Zhang, Ning-Ping
    Xu, Ru-Chen
    Zhang, Guang-Cong
    Liu, Zhi-Yong
    Abuduwaili, Weinire
    Wang, Fu
    Yu, Xiang-Nan
    Shi, Xuan
    Song, Guang-Qi
    Wu, Hao
    Liu, Tao-Tao
    Shen, Xi-Zhong
    Deng, Bin
    Weng, Shu-Qiang
    Dong, Ling
    Zhu, Ji-Min
    JOURNAL OF TRANSLATIONAL MEDICINE, 2021, 19 (01)
  • [33] Glutamine Antagonist JHU083 Normalizes Aberrant Glutamate Production and Cognitive Deficits in the EcoHIV Murine Model of HIV-Associated Neurocognitive Disorders (vol 14, pg 391, 2019)
    Nedelcovych, Michael T.
    Kim, Boe-Hyun
    Zhu, Xiaolei
    Lovell, Lyndah E.
    Manning, Arena A.
    Kelschenbach, Jennifer
    Hadas, Eran
    Chao, Wei
    Prchalova, Eva
    Dash, Ranjeet P.
    Wu, Ying
    Alt, Jesse
    Thomas, Ajit G.
    Rais, Rana
    Kamiya, Atsushi
    Volsky, David J.
    Slusher, Barbara S.
    JOURNAL OF NEUROIMMUNE PHARMACOLOGY, 2021, 16 (03) : 693 - 693
  • [34] Therapeutic Approaches Targeting Proteins in Tumor-Associated Macrophages and Their Applications in Cancers
    Wu, Deyang
    Liu, Xiaowei
    Mu, Jingtian
    Yang, Jin
    Wu, Fanglong
    Zhou, Hongmei
    BIOMOLECULES, 2022, 12 (03)
  • [35] Heme oxygenase-1 orchestrates the immunosuppressive program of tumor-associated macrophages
    Alaluf, Emmanuelle
    Vokaer, Benoit
    Detavernier, Aurelie
    Azouz, Abdulkader
    Splittgerber, Marion
    Carrette, Alice
    Boon, Louis
    Libert, Frederick
    Soares, Miguel
    Le Moine, Alain
    Goriely, Stanislas
    JCI INSIGHT, 2020, 5 (11)
  • [36] Leptin Augments Antitumor Immunity in Obesity by Repolarizing Tumor-Associated Macrophages
    Dudzinski, Stephanie O.
    Bader, Jackie E.
    Beckermann, Kathryn E.
    Young, Kirsten L.
    Hongo, Rachel
    Madden, Matthew Z.
    Abraham, Abin
    Reinfeld, Bradley E.
    Ye, Xiang
    MacIver, Nancie J.
    Giorgio, Todd D.
    Rathmell, Jeffrey C.
    JOURNAL OF IMMUNOLOGY, 2021, 207 (12): : 3122 - 3130
  • [37] Arg1 expression defines immunosuppressive subsets of tumor-associated macrophages
    Arlauckas, Sean P.
    Garren, Seth B.
    Garris, Chris S.
    Kohler, Rainer H.
    Oh, Juhyun
    Pittet, Mikael J.
    Weissleder, Ralph
    THERANOSTICS, 2018, 8 (21): : 5842 - 5854
  • [38] Subversion of infiltrating prostate macrophages to a mixed immunosuppressive tumor-associated macrophage phenotype
    Boibessot, Clovis
    Molina, Oscar
    Lachance, Gabriel
    Tav, Christophe
    Champagne, Audrey
    Neveu, Bertrand
    Pelletier, Jean-Francois
    Pouliot, Frederic
    Fradet, Vincent
    Bilodeau, Steve
    Fradet, Yves
    Bergeron, Alain
    Toren, Paul
    CLINICAL AND TRANSLATIONAL MEDICINE, 2022, 12 (01):
  • [39] VSIG4-expressing tumor-associated macrophages impair anti-tumor immunity
    Jung, Keunok
    Jeon, You-kyoung
    Jeong, Dae Hoon
    Byun, Jung Mi
    Bogen, Bjarne
    Choi, Inhak
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2022, 628 : 18 - 24
  • [40] IL-28B reprograms tumor-associated macrophages to promote anti-tumor effects in colon cancer
    Cheng, Dalei
    Wang, Haiyan
    Cheng, Hongyan
    Zhang, Hui
    Dong, Guanjun
    Yan, Fenglian
    Ning, Zhaochen
    Wang, Changying
    Wei, Li
    Zhang, Xin
    Zhang, Junfeng
    Xiong, Huabao
    INTERNATIONAL IMMUNOPHARMACOLOGY, 2022, 109
12345