Regulation of DC metabolism by nitric oxide in murine GM-CSF cultures

被引：0

作者：

Minarrieta, Lucia ^{[1
]}

Godoy, Gloria J. ^{[2
]}

Velazquez, Lis N. ^{[2
,6
]}

Ghorbani, Peyman ^{[1
]}

Sparwasser, Tim ^{[2
]}

Berod, Luciana ^{[3
,4
,5
]}

机构：

[1] Univ Ottawa, Dept Biochem Microbiol & Immunol, Ottawa, ON, Canada

[2] Johannes Gutenberg Univ Mainz, Univ Med Ctr, Inst Med Microbiol & Hyg, Mainz, Germany

[3] Johannes Gutenberg Univ Mainz, Univ Med Ctr, Inst Mol Med, Mainz, Germany

[4] Univ Med Ctr Mainz, Res Ctr Immunotherapy FZI, Mainz, Germany

[5] Johannes Gutenberg Univ Mainz, Univ Med Ctr, Inst Mol Med, Langenbeckstr 1, D-55131 Mainz, Germany

[6] Univ Med Ctr Hamburg Eppendorf, Dept Med, Hamburg, Germany

来源：

EUROPEAN JOURNAL OF IMMUNOLOGY | 2023年 / 53卷 / 02期

关键词：

DC metabolism; dendritic cells; GM-CSF; in vitro culture; nitric oxide;

D O I：

10.1002/eji.202149691

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The CD11c(+)MHCII(+) compartment within GM-CSF cultures consists of a MHCII(low)CD11b(high) population (GM-Macs) and a MHCII(high)CD11b(int) population (GM-DCs), with different metabolic profiles. GM-Macs upregulate iNOS and produce nitric oxide (NO) upon TLR activation inhibiting mitochondrial respiration (OXPHOS) while promoting glycolytic metabolism in GM-DCs, which naturally do not express iNOS. #& DAG;

引用

页数：4

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