Regulation of DC metabolism by nitric oxide in murine GM-CSF cultures

被引：0
|
作者：
Minarrieta, Lucia [1 ]
Godoy, Gloria J. [2 ]
Velazquez, Lis N. [2 ,6 ]
Ghorbani, Peyman [1 ]
Sparwasser, Tim [2 ]
Berod, Luciana [3 ,4 ,5 ]
机构：
[1] Univ Ottawa, Dept Biochem Microbiol & Immunol, Ottawa, ON, Canada
[2] Johannes Gutenberg Univ Mainz, Univ Med Ctr, Inst Med Microbiol & Hyg, Mainz, Germany
[3] Johannes Gutenberg Univ Mainz, Univ Med Ctr, Inst Mol Med, Mainz, Germany
[4] Univ Med Ctr Mainz, Res Ctr Immunotherapy FZI, Mainz, Germany
[5] Johannes Gutenberg Univ Mainz, Univ Med Ctr, Inst Mol Med, Langenbeckstr 1, D-55131 Mainz, Germany
[6] Univ Med Ctr Hamburg Eppendorf, Dept Med, Hamburg, Germany
来源：
EUROPEAN JOURNAL OF IMMUNOLOGY | 2023年 / 53卷 / 02期
关键词：
DC metabolism; dendritic cells; GM-CSF; in vitro culture; nitric oxide;
D O I：
10.1002/eji.202149691
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The CD11c(+)MHCII(+) compartment within GM-CSF cultures consists of a MHCII(low)CD11b(high) population (GM-Macs) and a MHCII(high)CD11b(int) population (GM-DCs), with different metabolic profiles. GM-Macs upregulate iNOS and produce nitric oxide (NO) upon TLR activation inhibiting mitochondrial respiration (OXPHOS) while promoting glycolytic metabolism in GM-DCs, which naturally do not express iNOS. #& DAG;
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页数：4
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