Preparation and evaluation of water-soluble chondroitin sulfate-curcumin conjugate

被引：4
|
作者：
Long, Lang [1 ]
Yang, Zhiqiang [1 ]
Zeng, Kaicheng [1 ]
Huang, Zhishen [1 ]
Hou, Xuedan [1 ]
Zhao, Hongxia [1 ]
机构：
[1] Guangdong Univ Technol, Sch Biomed & Pharmaceut Sci, Guangzhou 510090, Peoples R China
来源：
MATERIALS LETTERS | 2023年 / 351卷
基金：
中国国家自然科学基金;
关键词：
Curcumin; Chondroitin sulfate; Particles; Solubility; Nanosize; Toxicity;
D O I：
10.1016/j.matlet.2023.135035
中图分类号：
T [工业技术];
学科分类号：
08 ;
摘要：
Curcumin (Cur) is widely known for its medicinal properties. However, the extremely poor solubility of Cur in aqueous solutions limits its use in pharmaceutical applications. A water-soluble chondroitin sulfate-curcumin conjugate (CS-Cur) was synthesized in order to improve the solubility of Cur in this paper. The CS-Cur was characterized by nuclear magnetic resonance (NMR), fourier transform infrared spectroscopy (FTIR), and transmission electron microscope (TEM). The anti-tumor activity of CS-Cur was detected by live/dead cell staining assay and MTT. The results showed that CS-Cur conjugates exhibited excellent solubility in water, comparing with pure Cur. CS-Cur had significantly inhibitory effect on tumor cells in a dose-dependent manner.
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页数：5
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