Spectral characteristics and interrogation of a fiber-optic ball resonator biosensor modulated by a tilted fiber Bragg grating

被引：4

作者：

Sypabekova, Marzhan ^{[1
,2
]}

Amantayeva, Aida ^{[1
]}

Gonzalez-Vila, Alvaro ^{[3
]}

Shaimerdenova, Madina ^{[1
,4
]}

Caucheteur, Christophe ^{[3
]}

Tosi, Daniele ^{[1
,4
]}

机构：

[1] Nazarbayev Univ, Sch Engn & Digital Sci, 53 Kabanbay Batyr, Astana 010000, Kazakhstan

[2] Baylor Univ, Dept Elect & Comp Engn, Waco, TX USA

[3] Univ Mons, Electromagnetism & Telecommun Dept, B-7000 Mons, Belgium

[4] Natl Lab Astana, Lab Biosensors & Bioinstruments, 53 Kabanbay Batyr, Astana 010000, Kazakhstan

来源：

OPTICAL FIBER TECHNOLOGY | 2023年 / 79卷

关键词：

Fiber optic biosensors; Cancer biomarker detection; Ball resonator; Tilted fiber Bragg grating (TFBG); Optical biosensors; HER2 (human epidermal growth factor receptor 2); SURFACE-PLASMON RESONANCE; OPTICAL-FIBER; SENSOR;

D O I：

10.1016/j.yofte.2023.103354

中图分类号：

TM [电工技术]; TN [电子技术、通信技术];

学科分类号：

0808 ; 0809 ;

摘要：

In this work, we describe the design and analyze the characteristic of a fiber-optic biosensing device formed by a fiber-tip ball resonator (BR) assisted by an in-line tilted fiber Bragg grating (TFBG). The BR-TFBG device acts as miniature fiber-tip biosensor, characterized by a broad reflection spectrum remodulated by the cladding modes of the grating that enhance the amplitude sensitivity. We demonstrate an interrogation method that improves the sensitivity on the cladding mode comb, showing a sensitivity up to 274.0 dB/RIU in amplitude by using polarization-based analysis, and 154.7 nm/RIU for wavelength shift by using a cross-correlation method. Then, we demonstrate the biosensing application of the BR-TFBG for the detection of human epidermal growth factor receptor-2 (HER2) in buffer, within 0.5 - 128.0 ng/ml concentration.

引用

页数：9

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