Palladium-Catalyzed Branch- and Z-Selective Allylic C-H Amination with Aromatic Amines

被引：8

作者：

Liu, Rui ^{[1
]}

Shen, Meng-Lan ^{[1
]}

Fan, Lian-Feng ^{[1
]}

Zhou, Xiao-Le ^{[1
]}

Wang, Pu-Sheng ^{[1
]}

Gong, Liu-Zhu ^{[1
]}

机构：

[1] Univ Sci & Technol China, Dept Chem, 96 Jinzhai Rd, Hefei 230026, Peoples R China

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2023年 / 62卷 / 04期

基金：

国家重点研发计划;

关键词：

Alkene; Amination; C-H Activation; Palladium Catalysis; Regioselection; TERMINAL ALKENES; NATURAL-PRODUCTS; FUNCTIONALIZATION; BONDS; STRATEGIES; CARBONYL;

D O I：

10.1002/anie.202211631

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Allylamines are important building blocks in the synthesis of bioactive compounds. The direct coupling of allylic C-H bonds and commonly available amines is a major synthetic challenge. An allylic C-H amination of 1,4-dienes has been accomplished by palladium catalysis. With aromatic amines, branch-selective allylic aminations are favored to generate thermodynamically unstable Z-allylamines. In addition, more basic aliphatic cyclic amines can also engage in the reaction, but linear dienyl allylic amines are the major products.

引用

页数：5

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