Radical Hydro-Fluorosulfonylation of Propargylic Alcohols via Electron Donor-Acceptor Photoactivation

被引：9

作者：

Zhang, Yingyin ^{[1
]}

Feng, Qingyuan ^{[1
]}

Zheng, Yu ^{[1
]}

Lu, Yanju ^{[1
]}

Liao, Saihu ^{[2
]}

Huang, Shenlin ^{[1
,3
]}

机构：

[1] Nanjing Forestry Univ, Jiangsu Coinnovat Ctr Efficient Proc & Utilizat F, Int Innovat Ctr Forest Chem & Mat, Nanjing 210037, Jiangsu, Peoples R China

[2] Xiamen Univ, State Key Lab Phys Chem Solid Surfaces, Xiamen 361005, Fujian, Peoples R China

[3] Hunan Normal Univ, Coll Chem & Chem Engn, Key Lab Chem Biol & Tradit Chinese Med Res, Minist Educ China, Changsha 410081, Hunan, Peoples R China

来源：

ORGANIC LETTERS | 2024年 / 26卷 / 07期

基金：

中国国家自然科学基金;

关键词：

D O I：

10.1021/acs.orglett.4c00010

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A radical hydro-fluorosulfonylation of propargyl alcohols with FSO2Cl is presented based on the photoactivation of the electron donor-acceptor (EDA) complex. The reaction avoids the requirement for photocatalysts, bases, hydrogen donor reagents, any other additives, and harsh conditions, enabling the facile synthesis of various functionalized gamma-hydroxy (E)-alkenylsulfonyl fluorides. These multifunctional sulfonyl fluorides can be further diversified, providing access to various privileged molecules of biological relevance.

引用

页码：1410 / 1415

页数：6

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