Targeting Venetoclax Resistance in TP53-Mutated Acute Myeloid Leukemia

被引：0
|
作者：
Vanttinen, Ida [1 ,2 ]
Ruokoranta, Tanja [1 ]
Saad, Joseph J. [1 ,2 ]
Kytola, Sari [3 ]
Hellesoy, Monica [4 ]
Gullaksen, Stein-Erik [4 ]
Ettala, Pia-Sofia [5 ]
Pyorala, Marja [6 ]
Rimpilainen, Johanna [7 ]
Siitonen, Timo [8 ]
Wennerberg, Krister [9 ]
Gjertsen, Bjorn T. [4 ,10 ]
Heckman, Caroline A. [1 ,2 ]
Kontro, Mika [1 ,2 ,3 ,11 ]
Kuusanmaki, Heikki [1 ,2 ,9 ,11 ]
机构：
[1] Univ Helsinki, Inst Mol Med Finland FIMM, HiLIFE, Helsinki, Finland
[2] ICAN Digital Precis Canc Med Flagship, Helsinki, Finland
[3] Helsinki Univ Hosp, Dept Hematol, Comprehens Canc Ctr, Helsinki, Finland
[4] Helse Bergen, Hematol Sect, Dept Med, Bergen, Norway
[5] Turku Univ Hosp, Dept Clin Hematol, Turku, Finland
[6] Kuopio Univ Hosp, Dept Med, Kuopio, Finland
[7] Tampere Univ Hosp, Dept Internal Med, Tampere, Finland
[8] Oulu Univ Hosp, Canc Ctr, Hematol, Oulu, Finland
[9] Univ Copenhagen, Biotech Res & Innovat Ctr BRIC, Copenhagen, Denmark
[10] Univ Bergen, Dept Clin Sci, Ctr Canc Biomarkers CCBIO, Bergen, Norway
[11] Fdn Finnish Canc Inst, Helsinki, Finland
来源：
BLOOD | 2023年 / 142卷
关键词：
D O I：
10.1182/blood-2023-189340
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
引用
收藏
页数：4
相关论文
共 50 条
  • [31] TP53-mutated Acute Myeloid Leukemia with Myelodysplasia-Related Changes and TherapyRelated Acute Myeloid Leukemia Have Comparable TP53 Mutational Signature and Clinical Features
    Tashakori, Mehrnoosh
    Tapan, Kadia
    Loghavi, Sanam
    Tang, Zhenya
    Routbort, Mark
    Ravandi-Kashani, Farhad
    Khoury, Joseph
    MODERN PATHOLOGY, 2022, 35 (SUPPL 2) : 1027 - 1028
  • [32] Impact of induction intensity and transplantation on outcomes of patients with complex karyotype and TP53-mutated acute myeloid leukemia
    Jamy, Omer
    Diebold, Kendall
    Davis, Kenneth
    Bachiashvili, Kimo
    Rangaraju, Sravanti
    Vachhani, Pankit
    Godby, Kelly N.
    Salzman, Donna
    Bhatia, Ravi
    BONE MARROW TRANSPLANTATION, 2023, 58 (07) : 823 - 825
  • [33] Impact of induction intensity and transplantation on outcomes of patients with complex karyotype and TP53-mutated acute myeloid leukemia
    Omer Jamy
    Kendall Diebold
    Kenneth Davis
    Kimo Bachiashvili
    Sravanti Rangaraju
    Pankit Vachhani
    Kelly N. Godby
    Donna Salzman
    Ravi Bhatia
    Bone Marrow Transplantation, 2023, 58 : 823 - 825
  • [34] Decitabine salvage for TP53-mutated, relapsed/refractory acute myeloid leukemia after cytotoxic induction therapy
    Ferraro, Francesca
    Gruszczynska, Agata
    Ruzinova, Marianna B.
    Miller, Christopher A.
    Percival, Mary Elizabeth
    Uy, Geoffrey L.
    Pusic, Iskra
    Jacoby, Meagan A.
    Christopher, Mathew J.
    Kim, Miriam Y.
    Westervelt, Peter
    Cashen, Amanda F.
    Schroeder, Mark A.
    DiPersio, John F.
    Abboud, Camille N.
    Wartman, Lukas D.
    Gao, Feng
    Link, Daniel C.
    Ley, Timothy J.
    Welch, John S.
    HAEMATOLOGICA, 2022, 107 (07) : 1709 - 1713
  • [35] TP53-mutated Acute Myeloid Leukemia with Myelodysplasia-Related Changes and Therapy-Related Acute Myeloid Leukemia Have Comparable TP53 Mutational Signature and Clinical Features
    Tashakori, Mehrnoosh
    Tapan, Kadia
    Loghavi, Sanam
    Tang, Zhenya
    Routbort, Mark
    Ravandi-Kashani, Farhad
    Khoury, Joseph
    LABORATORY INVESTIGATION, 2022, 102 (SUPPL 1) : 1027 - 1028
  • [36] Haploidentical haematopoietic stem cell transplantation for TP53-mutated acute myeloid leukaemia
    Huang, Ting
    Xu, Lanping
    Zhang, Xiaohui
    Chang, Yingjun
    Mo, Xiaodong
    Sun, Yuqian
    Huang, Xiaojun
    Wang, Yu
    BRITISH JOURNAL OF HAEMATOLOGY, 2023, 200 (04) : 494 - 505
  • [37] Prognostic and Therapeutic Implications of Mutant TP53 Variant Allelic Frequency in Adults with Newly Diagnosed TP53-Mutated Acute Myeloid Leukemia
    Short, Nicholas J.
    Montalban-Bravo, Guillermo
    Hwang, Hyunsoo
    Ning, Jing
    Franquiz, Miguel
    Kanagal-Shamanna, Rashmi
    Patel, Keyur
    Dinardo, Courtney D.
    Ravandi, Farhad
    Garcia-Manero, Guillermo
    Takahashi, Koichi
    Konopleva, Marina
    Daver, Naval
    Jabbour, Elias
    Yilmaz, Musa
    Issa, Ghayas C.
    Andreeff, Michael
    Kadia, Tapan M.
    BLOOD, 2020, 136
  • [38] FOLFOX resistance in TP53-mutated Metastatic Colorectal Cancer: mechanism and selective targeting
    Hollande, Frederic
    Behrenbruch, Corina
    Foroutan, Momeneh
    Simpson, Kaylene
    Heriot, Alexander
    CANCER SCIENCE, 2023, 114 : 739 - 739
  • [39] Eprenetapopt combined with venetoclax and azacitidine in TP53-mutated acute myeloid leukaemia: a phase 1, dose-finding and expansion study
    Garcia-Manero, Guillermo
    Goldberg, Aaron D.
    Winer, Eric S.
    Altman, Jessica K.
    Fathi, Amir T.
    Odenike, Olatoyosi
    Roboz, Gail J.
    Sweet, Kendra
    Miller, Crystal
    Wennborg, Anders
    Hickman, Denice K.
    Kanagal-Shamanna, Rashmi
    Kantarjian, Hagop
    Lancet, Jeffrey
    Komrokji, Rami
    Attar, Eyal C.
    Sallman, David A.
    LANCET HAEMATOLOGY, 2023, 10 (04): : E272 - E283
  • [40] Clinical outcomes and characteristics of patients with TP53-mutated acute myeloid leukemia or myelodysplastic syndromes: a single center experience*
    Bewersdorf, Jan Philipp
    Shallis, Rory M.
    Gowda, Lohith
    Wei, Wei
    Hager, Karl
    Isufi, Iris
    Kim, Tae Kon
    Pillai, Manoj M.
    Seropian, Stuart
    Podoltsev, Nikolai A.
    Gore, Steven D.
    Siddon, Alexa J.
    Zeidan, Amer M.
    LEUKEMIA & LYMPHOMA, 2020, 61 (09) : 2180 - 2190
12345