Increased COVID-19 Mortality and Deficient SARS-CoV-2 Immune Response Are Not Associated with Higher Levels of Endemic Coronavirus Antibodies

被引:2
|
作者
Adhikari, Bindu [1 ,2 ]
Oltz, Eugene M. [3 ]
Bednash, Joseph S. [4 ]
Horowitz, Jeffrey C. [4 ]
Amimo, Joshua O. [2 ]
Raev, Sergei A. [2 ]
Fernandez, Soledad [5 ,6 ]
Anghelina, Mirela [5 ,6 ]
Liu, Shan-Lu [3 ,7 ,8 ,9 ]
Rubinstein, Mark P. [10 ,11 ]
Jones, Daniel M. [12 ]
Saif, Linda J. [1 ,2 ]
Vlasova, Anastasia N. [1 ,2 ]
机构
[1] Ohio State Univ, Coll Vet Med, Dept Vet Prevent Med, Wooster, OH 44691 USA
[2] Ohio State Univ, Coll Food Agr & Environm Sci, Ctr Food Anim Hlth, Dept Anim Sci,OARDC, Wooster, OH 44691 USA
[3] Ohio State Univ, Dept Microbial Infect & Immun, Columbus, OH 43210 USA
[4] Ohio State Univ, Dept Internal Med, Div Pulm Crit Care & Sleep Med, Columbus, OH 43210 USA
[5] Ohio State Univ, Coll Med, Dept Biomed Informat, Columbus, OH 43210 USA
[6] Ohio State Univ, Ctr Biostat, Columbus, OH 43210 USA
[7] Ohio State Univ, Ctr Retrovirus Res, Columbus, OH 43210 USA
[8] Ohio State Univ, Dept Vet Biosci, Columbus, OH 43210 USA
[9] Ohio State Univ, Infect Dis Inst, Viruses & Emerging Pathogens Program, Columbus, OH 43210 USA
[10] Ohio State Univ, Dept Internal Med, Div Med Oncol, Columbus, OH 43210 USA
[11] Ohio State Univ, Pelotonia Inst Immunooncol, James Comprehens Canc Ctr, Columbus, OH 43210 USA
[12] Ohio State Univ, Dept Pathol, Columbus, OH 43210 USA
来源
IMMUNO | 2023年 / 3卷 / 03期
关键词
SARS-CoV-2; common cold coronavirus; serological testing; immunocompromised patients; antibodies;
D O I
10.3390/immuno3030020
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
The impact of pre-existing common cold coronavirus (CCCoV) antibodies (Abs) on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) immune responses and pathogenesis remains poorly defined. We evaluated these associations in a cohort of hospitalized patients with COVID-19 and respiratory failure of varying severity. Patients with respiratory failure from other causes (non-COVID-19) were evaluated as controls. We demonstrated a positive correlation between levels of CCCoV and SARS-CoV-2 Abs using CCCoV and SARS-CoV-2 N and S protein peptide-specific ELISA. Consistent with the above, moderately increased levels of CCCoV-specific Abs in non-COVID-19 vs. COVID-19 patients suggest potential protective effects. Further, higher SARS-CoV-2 N protein-specific and CCCoV Ab levels were observed among surviving vs. non-surviving COVID-19 positive patients. However, the highest SARS-CoV-2 N and S protein-specific IgG and IgA Ab levels were noted in the patients with the most severe clinical disease. Finally, advanced age, cancer and immunosuppression were associated with significantly higher mortality and reduced SARS-CoV-2 and CCCoV Ab levels. Thus, our data highlight that sufficient SARS-CoV-2 N protein-specific Ab responses improve clinical outcomes in severely ill COVID-19 patients. We also confirmed that pre-existing CCCoV-specific Abs do not inhibit the SARS-CoV-2 Ab response and may further reduce the prevalence and/or severity of COVID-19.
引用
收藏
页码:330 / 345
页数:16
相关论文
共 50 条
  • [31] Atrial fibrillation is related to higher mortality in COVID-19/SARS-CoV-2 pneumonia infection
    Denegri, Andrea
    Morelli, Marianna
    Pezzuto, Giuseppe
    Malavasi, Vincenzo Livio
    Boriani, Giuseppe
    CARDIOLOGY JOURNAL, 2021, 28 (06) : 973 - 975
  • [32] Monoclonal antibodies for COVID-19 therapy and SARS-CoV-2 detection
    Hwang, Yu-Chyi
    Lu, Ruei-Min
    Su, Shih-Chieh
    Chiang, Pao-Yin
    Ko, Shih-Han
    Ke, Feng-Yi
    Liang, Kang-Hao
    Hsieh, Tzung-Yang
    Wu, Han-Chung
    JOURNAL OF BIOMEDICAL SCIENCE, 2022, 29 (01)
  • [33] A COVID-19 Patient with Repeatedly Undetectable SARS-CoV-2 Antibodies
    Goetz, Lianna
    Yang, Jianbo
    Greene, Wallace
    Zhu, Yusheng
    JOURNAL OF APPLIED LABORATORY MEDICINE, 2020, 5 (06): : 1401 - 1405
  • [34] Detection of antibodies against SARS-CoV-2 in patients with COVID-19
    Du, Zhe
    Zhu, Fengxue
    Guo, Fuzheng
    Yang, Bo
    Wang, Tianbing
    JOURNAL OF MEDICAL VIROLOGY, 2020, 92 (10) : 1735 - 1738
  • [35] IMMUNITY TO COVID-19 AND ISSUES OF SCREENING FOR SARS-COV-2 ANTIBODIES
    Mayanskiy, N. A.
    BULLETIN OF RUSSIAN STATE MEDICAL UNIVERSITY, 2020, (03): : 25 - 27
  • [36] SARS-CoV-2 Neutralizing Antibodies for COVID-19 Prevention and Treatment
    Li, Dapeng
    Sempowski, Gregory D.
    Saunders, Kevin O.
    Acharya, Priyamvada
    Haynes, Barton F.
    ANNUAL REVIEW OF MEDICINE, 2022, 73 : 1 - 16
  • [37] Monoclonal antibodies for COVID-19 therapy and SARS-CoV-2 detection
    Yu-Chyi Hwang
    Ruei-Min Lu
    Shih-Chieh Su
    Pao-Yin Chiang
    Shih-Han Ko
    Feng-Yi Ke
    Kang-Hao Liang
    Tzung-Yang Hsieh
    Han-Chung Wu
    Journal of Biomedical Science, 29
  • [38] Absent immune response to SARS-CoV-2 in a 3-month recurrence of coronavirus disease 2019 (COVID-19) case
    Guosheng Gao
    Zhe Zhu
    Lingyan Fan
    Shuyuan Ye
    Zuoan Huang
    Qiaoyun Shi
    Yedan Sun
    Qifa Song
    Infection, 2021, 49 : 57 - 61
  • [39] Absent immune response to SARS-CoV-2 in a 3-month recurrence of coronavirus disease 2019 (COVID-19) case
    Gao, Guosheng
    Zhu, Zhe
    Fan, Lingyan
    Ye, Shuyuan
    Huang, Zuoan
    Shi, Qiaoyun
    Sun, Yedan
    Song, Qifa
    INFECTION, 2021, 49 (01) : 57 - 61
  • [40] Management of the SARS-CoV-2 (COVID-19) coronavirus epidemic in hemodialysis units
    Dolores Arenas, Maria
    Villar, Judit
    Gonzalez, Cristina
    Cao, Higinio
    Collado, Silvia
    Crespo, Marta
    Pablo Horcajada, Juan
    Pascual, Julio
    NEFROLOGIA, 2020, 40 (03): : 258 - 264